Project description:In this study, whole blood samples were used to determine the gene expression of febrile culture confirmed enteric fever cases (ST = S. Typhi; SPT = S. Paratyphi), febrile culture negative individuals presenting to hospital in Kathamandu (sEF = suspected enteric fever), and healthy community controls (CTRL).
Project description:Non-Hodgkin Lymphoma (NHL) is the main cancer-related mortality for people living with HIV (PLWH), who have elevated risk for lymphoma relative to the general population. NHL genetic and molecular classifications have been intensely studied and correlated with clinical outcomes, but critical unanswered questions relevant to malignancy persist. For example, tumors positive for Epstein-Barr virus (EBV) account for 30-50% of HIV-associated NHLs, are particularly aggressive, and have poorer clinical outcomes – yet insights on the nature of EBV in NHL pathogenesis or potential therapeutic vulnerabilities have been limited. Here, we examined HIV-associated NHLs stratified by cell of origin (COO), molecular subtype, and EBV status using genome-wide spatial transcriptomic analyses.