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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors (ATAC-Seq)

ABSTRACT: The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors (ATAC-Seq)

PROVIDER: PRJNA1149013 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30275165_1.fastq.gz	Fastqsanger.gz
	SRR30275165_2.fastq.gz	Fastqsanger.gz
	SRR30275166_1.fastq.gz	Fastqsanger.gz
	SRR30275166_2.fastq.gz	Fastqsanger.gz
	SRR30275167_1.fastq.gz	Fastqsanger.gz

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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors (RNA-Seq)

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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors (RNA-Seq)

Project description:Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with a 61.9% overall survival rate, metastatic disease is often fatal due to resistance to systemic therapies which underscores the urgent need for effective treatments. MPNSTs frequently harbor inactivating driver mutations in the PRC2 epigenetic repressor complex suggesting epigenetic therapies may represent a specific vulnerability in these tumors. Here, we investigate the role of the LSD1-HDAC1-CoREST (LHC) repressor complex in mediating MPNST tumor growth and progression. Our findings demonstrate that the LHC small molecule inhibitor, corin, induces apoptosis and significantly inhibits proliferation in MPNST cells. Transcriptomic analysis of corin-treated MPNST cells demonstrates specific increases in genes associated with axonogenesis and neuronal differentiation as well as altered extracellular matrix; additionally, corin treatment is shown to inhibit MPNST invasion in vitro. These results underscore the critical role of the LHC complex in facilitating MPNST growth and progression and suggest that targeting the LHC complex represents a promising therapeutic approach for this aggressive malignancy.

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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors (ATAC-Seq)

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Malignant peripheral nerve sheath tumor (MPNST) tumor samples

Project description:Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma. Comprehensive proteomic profiles of 23 MPNST tumor specimens were obtained using LC-MS/MS. Among 23 tumor specimens, 13 patients showed favorable prognosis and 10 did local recurrence/distant metastasis.

2022-12-22 | PXD030585 | JPOST Repository

Methylation profiling of malignant peripheral nerve sheath tumour samples

Project description:Methylation profiling of malignant peripheral nerve sheath tumours (MPNSTs), epithelioid MPNSTs, sarcoma NOS, melanomas and spindle cell/sclerosing rhabdomyosarcomas.

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Comparative genomic hybridization of human malignant peripheral nerve sheath tumors and normal reference DNA

Project description:DNA copy number profiling of malignant peripheral nerve sheath tumours

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Project description:We performed a genome-wide CRISPRi screen to identify potential contributors to radioresistance in the JH02.2 malignant peripheral nerve sheath tumor (MPNST) cell line.

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MicroRNA expression profiles in malignant peripheral nerve sheath tumors

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Distinct immunomodulatory pathways mediate radiotherapy response in malignant peripheral nerve sheath tumors [scRNA-Seq]

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