Project description:Vanderbilt Familial Pulmonary Fibrosis: Identification of a conserved sequence of disease progression in Idiopathic Pulmonary Fibrosis
Project description:Vanderbilt Familial Pulmonary Fibrosis: Identification of a conserved sequence of disease progression in Idiopathic Pulmonary Fibrosis
Project description:We analyzed via microarray gene expression profiles from patients with familial pulmonary fibrosis and HPS-1 pulmonary fibrosis collected under IRB-approved protocols.
Project description:The murine pulmonary response is strain specific. Susceptible strains such as C57BL6/J experience an inflammatory response followed by progressive lung disease. Resistant strains such as Balb/c do not experience significant degrees of inflammation or fibrosis. This study aims to determine the genetic basis of sensitivity differences between strains Keywords: other