Maternal ancestry reveals cyclical aging of the mammary gland.
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1153605 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:the present provocative data that in addition to the expected progressive age-related involution, mammary gland aging can occur in a cyclical pattern and is dictated by maternal ancestry. In cyclical aging, mammary glands of 11 and 19 months old mice share genetic and proteomic signatures, which are enriched in breast cancer-related pathways, but are absent at 3 and 14 months. Since incidence of breast cancer shows a bimodal age distribution at 45 (~11m in mice) and 65 (~19m in mice) in human populations, cyclical aging may contribute to these peaks of cancer susceptibility. Conversely, since the mammary glands at 3 and 14 months cluster together hierarchically, the cancer-associated peaks seem separated by a rejuvenation phase. Since cyclical aging is observed in mice with extended lifespan, these findings raise the possibility that if oncogenic mutations are avoided during the pro-oncogenic phases, through its rejuvenation phase, cyclical aging may impact multiple organs leading to extended longevity.
2025-08-01 | GSE275925 | GEO
Project description:Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. RNA-seq was performed to identify gene expression differences as a result of maternal nutrition in ewe offspring during their first parity. Samples were collected in late pregnancy and during lactation, allowing us to examine gene expression changes during maturation of the ovine mammary gland. Three biological replicates were sequenced for each of the treatment conditions (maternal nutrition: sub-maintenance, maintenance, and ad libitum) and time points (late pregnancy and lactation). Each biological replicate consisted of RNA from multiple individuals (late pregnancy n=3, lactation n=2).
2015-07-29 | E-GEOD-71424 | biostudies-arrayexpress
Project description:Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. RNA-seq was performed to identify gene expression differences as a result of maternal nutrition in ewe offspring during their first parity. Samples were collected in late pregnancy and during lactation, allowing us to examine gene expression changes during maturation of the ovine mammary gland.
2015-07-29 | GSE71424 | GEO
Project description:Protein Dynamic Landscape during Mouse Mammary Gland Development from virgin to pregnant, lactating and involuting stage.
2023-10-26 | PXD046407 |
Project description:This submission contains the mass spectrometry files for the manuscript by Aurelie Lacouture et al. that describes the quantitative proteomics analysis of mouse mammary gland epithelial organoids proteome. Experiments were performed from mammary glands organoids derived from mouse and the MS files were acquired on Orbitrap Fusion mass spectrometer. For questions, please contact Etienne Audet-Walsh (Etienne.Audet-Walsh@crchudequebec.ulaval.ca).
2025-12-01 | MSV000100067 | MassIVE
Project description:The main goal of this experiment was to contrast the gene expression of mammary gland tissues at three different tumoral stages : M/D-driven mammary gland small tumors vs mammary gland tissues that have been exposed to M/D but they did not develop a tumor (hyperplastic mammary gland) vs mammary gland tissues that were NOT expossed to M/D (normal mammary gland). Expression profile of 18 mice mammary gland tissues at 3 differents neoplastic stages before and after M/D expossure
2020-06-22 | GSE151197 | GEO
Project description:Mammary gland tumor immunoinfiltrate analysis
| PRJNA634255 | ENA
Project description:Mammary gland tumor immunoinfiltrate analysis
| PRJNA634093 | ENA