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Direct genetic transformation bypasses tumor-associated DNA methylation alterations (target enrichment)

ABSTRACT: Direct genetic transformation bypasses tumor-associated DNA methylation alterations (target enrichment)

PROVIDER: PRJNA1154661 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30497527_1.fastq.gz	Fastqsanger.gz
	SRR30497527_2.fastq.gz	Fastqsanger.gz
	SRR30497528_1.fastq.gz	Fastqsanger.gz
	SRR30497528_2.fastq.gz	Fastqsanger.gz
	SRR30497529_1.fastq.gz	Fastqsanger.gz

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Direct genetic transformation bypasses tumor-associated DNA methylation alterations

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Direct genetic transformation bypasses tumor-associated DNA methylation alterations (target enrichment)

Project description:Tumors represent dynamically evolving populations of mutant cells, and many advances have been made in understanding the biology of their progression. However, key unresolved questions remain about the conditions that support their initial transformation, which cannot be easily captured in patient populations but are instead modeled using transgenic cellular or animal systems. Here, we used extensive patient atlas data to define common features of the tumor DNA methylation landscape as they compare to healthy human cells and used this benchmark to screen 21 engineered human and mouse models for their ability to reproduce these patterns. Notably, we find that genetically induced cellular transformation can trigger global changes in DNA methylation levels that are consistent with extensive proliferation but rarely recapitulate the widespread de novo methylation of Polycomb targets as found in clinical samples. Our results raise pertinent questions about the relationship between genetic and epigenetic aspects of tumorigenesis and provide an important molecular reference for evaluating existing as well as newer tumor models.

2025-05-20 | GSE276082 | GEO

Direct genetic transformation bypasses tumor-associated DNA methylation alterations (RRBS)

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Direct genetic transformation bypasses tumor-associated DNA methylation alterations

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Aerobic bacterial enrichment cultures that degraded BPA andits transformation products

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Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling

Project description:Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling Keyword: genetic modification

2012-10-30 | GSE41451 | GEO

Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells

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Project description:Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation

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Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling

Project description:Hog1 bypasses stress-mediated downregulation of transcription by PolII redistribution and chromatin remodeling Keyword: genetic modification Three independent 200 ml cultures of wild-type strain were grown to mid-log phase in YPD rich medium at 30ºC

2012-10-30 | E-GEOD-41451 | biostudies-arrayexpress

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