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Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [scRNA-Seq]

ABSTRACT: Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [scRNA-Seq]

PROVIDER: PRJNA1155642 | ENA |

REPOSITORIES: ENA

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Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [scRNA-Seq]

Project description:Liver regeneration is supported by hepatocytes and, in certain conditions, biliary epithelial cells (BEC). BEC are facultative liver stem cells, able to form organoids in culture and engraft in damaged livers. However, BEC heterogeneity in the homeostatic liver remains to be fully elucidated. Here, we exploited in vivo systemic lentiviral vector (LV) administration to achieve efficient and life-long gene transfer to BEC in mice. We found that LV-marked BEC retain organoid-formation potential and predominantly respond to liver damage, however, are less clonogenic and display more hepatocyte-primed transcriptome compared to untransduced BEC. We thus identify a BEC subset committed to hepatocyte lineage in the absence of liver damage, characterized by a transcriptional network orchestrated by hepatocyte nuclear factor 4a. We also report in vivo targeting of such BEC in non-human primates. This work highlights intrinsic BEC heterogeneity and that in vivo LV gene transfer to the liver may persist following BEC-mediated repair of hepatic damage.

2025-09-01 | GSE276179 | GEO

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates

Project description:Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates

| PRJNA971871 | ENA

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [1]

Project description:Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [1]

| PRJNA971874 | ENA

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [2]

Project description:Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [2]

| PRJNA971875 | ENA

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [2]

Project description:To investigate the differences in the trascriptome of mouse cholangiocytes transduced in vivo by lentiviral vector compared to the untransduced counterpart

2024-05-11 | GSE232370 | GEO

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-11 | GSE232372 | GEO

Identification of hepatocyte-primed biliary epithelial cells in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates [1]

Project description:To investigate the differences in the trascriptome of mouse cholangiocytes marked with or without the Confetti reporter after induction of CreERT2-mediated recombination driven by Albumin promoter

2024-05-11 | GSE232369 | GEO

TNF is a homeostatic regulator of distinct epigenetically primed human osteoclast precursors

Project description:TNF is a homeostatic regulator of distinct epigenetically primed human osteoclast precursors

| PRJNA640824 | ENA

Primates

Project description:Primates

| PRJNA551411 | ENA

mRNA expression profiling of ERCP biliary brushings of malignant biliary strictures

Project description:Identification of differential gene expression uging endoscopic biliary brushings Bile duct brishings of benign biliary strictures and malignant biliary strictures, samples snap frozen in liquid nitrogen

2012-03-01 | E-GEOD-34166 | biostudies-arrayexpress

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