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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

ABSTRACT: Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

PROVIDER: PRJNA1157389 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30553778_1.fastq.gz	Fastqsanger.gz
	SRR30553778_2.fastq.gz	Fastqsanger.gz
	SRR30553779_1.fastq.gz	Fastqsanger.gz
	SRR30553779_2.fastq.gz	Fastqsanger.gz
	SRR30553780_1.fastq.gz	Fastqsanger.gz

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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

Project description:Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

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Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target

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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

Project description:In this project, we used single nucleus RNA-sequenicng to delineate the effects of artesunate on multiple types of cells in the heart.

2024-10-15 | GSE274781 | GEO

Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target

Project description:The ATAC-seq aims to examine the antifibrotic effects of artesunate on the epigenetic level in human primary fibroblasts

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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

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Gene Signature-guided Drug Screening Identified Narciclasine as a Potential Therapeutic Drug for Renal Interstitial Fibrosis

Project description:Chronic Kidney Disease (CKD) is characterized by progressive tubulointerstitial fibrosis (TIF), a condition not adequately addressed by existing therapies. To identify potential compounds that could slow or halt the progression of TIF, we established gene signatures of TIF using published human CKD renal transcriptome data, followed by high-throughput screening of compounds that could reverse TIF-associated gene expression using the LINCS L1000 database. The natural compound Narciclasine (Ncls), extracted from daffodils, was identified as a promising candidate. We validated the effects of Ncls on a TGF-β1-induced fibrosis model in vitro using mouse primary tubular epithelial cells (TECs) and rat fibroblast cell line (NRK49F). Results demonstrated that Ncls significantly inhibited the pro-inflammatory and pro-fibrotic effects induced by TGF-β1 in TECs. Additionally, in fibroblasts, Ncls markedly suppressed the proliferation and activation induced by TGF-β1. These findings not only confirm the therapeutic potential of Ncls in managing TIF but also highlight the efficacy of gene signature-based screening in identifying drugs for the treatment of CKD.

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Nesterenkonia ebinurensis strain:MD2

Project description:Nesterenkonia ebinurensis strain:MD2 Genome sequencing and assembly

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Ananas comosus cultivar:MD2

Project description:Ananas comosus cultivar:MD2 Genome sequencing and assembly

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Transcription profiling of rice plants under the Md2 (pF2.5) condition in shoots

Project description:In this series of experiments, we wanted to study the transcriptional responses of plants to different levels of water limitation. For mild drought stress, we controlled water potential (a scientific concept for dryness of soil) by using an automated watering system. This system adds water to soil based on the pF values reported by a pF sensor in soil. pF is a classical and widely used index of water potential that was first defined by Schofield (1935). For severe stress conditions, we withheld watering or even dried plants on a lab bench. Here, the transcriptional profiles were compared between well-watered and Md2-treated rice seedling shoots.<br>Md2 (Mild drought level 2): We designated Md2 as a term that means the level of drought severity corresponding to pF2.5, which is equal to a soil matric potential of -31.0 kPa. pF2.5: The value of pF shows the soil matric potential of -31.0 kPa. pF is an index that is equivalent to the effort required for plant root systems to extract water stored in soil.

2016-12-26 | E-MTAB-4135 | biostudies-arrayexpress

Kluyveromyces lactis strain:MD2/1

Project description:Kluyveromyces lactis strain:MD2/1 Genome sequencing

| PRJNA707006 | ENA