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EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus

ABSTRACT: EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus

PROVIDER: PRJNA1157452 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR30562500_1.fastq.gz	Fastqsanger.gz
	SRR30562500_2.fastq.gz	Fastqsanger.gz
	SRR30562501_1.fastq.gz	Fastqsanger.gz
	SRR30562501_2.fastq.gz	Fastqsanger.gz

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EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

Project description:Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), functioning independently of EBNA2 to regulate chromatin architecture and gene expression. Our study reveals that EBNA-LP binds to chromatin regions distinct from EBNA2 and facilitates the formation of long-distance chromatin loops by interacting with the cellular factor YY1. This interaction reconfigures the three-dimensional structure of the host genome, enhancing the integrity of topologically associating domains (TADs) and promoting the interaction between enhancers and promoters within these domains. In EBV-infected B cells, EBNA-LP strengthens YY1-mediated chromatin loops within TADs, which helps maintain stable regulatory programs essential for B cell transformation. Notably, EBNA-LP is crucial for establishing EBV-induced enhancers, yet it is not required for their maintenance once formed. Additionally, our data suggest a compensatory increase in CTCF binding in the absence of EBNA-LP, leading to more promiscuous chromatin interactions between TADs and a reduced TAD insulation at their boundaries. These findings provide new insights into the molecular mechanisms by which EBNA-LP contributes to B cell transformation and highlight potential therapeutic targets for disrupting EBV-driven oncogenesis

2025-06-10 | GSE276488 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

2025-06-10 | GSE276487 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

2025-06-10 | GSE276489 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ATAC-seq)

2025-06-10 | GSE276484 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (CUT&Run)

2025-06-10 | GSE276486 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ChIP-Seq)

2025-06-10 | GSE276485 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

| PRJNA1157455 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

| PRJNA1157460 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

| PRJNA1157459 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ATAC-seq)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ATAC-seq)

| PRJNA1157449 | ENA

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