Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

ABSTRACT: miRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

PROVIDER: PRJNA1159165 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30619030.fastq.gz	Fastqsanger.gz
	SRR30619031.fastq.gz	Fastqsanger.gz
	SRR30619032.fastq.gz	Fastqsanger.gz
	SRR30619033.fastq.gz	Fastqsanger.gz
	SRR30619034.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

miRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

Project description:Fresh resected lung tissues were obtained from nine tuberculosis patients with elevated pulmonary 18F-FDG avidity. Lung tissues with 18F-FDG avidity and nearby uninvolved tissues were profiled with miRNA sequencing.

2025-04-09 | GSE276819 | GEO

mRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

2025-04-09 | GSE277481 | GEO

Single cell RNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

Project description:Fresh resected lung tissues were obtained from six tuberculosis patients with elevated pulmonary 18F-FDG avidity. Lung tissues with 18F-FDG avidity and nearby uninvolved tissues were profiled with single-cell RNA sequencing.

2023-09-25 | GSE192483 | GEO

mRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

Project description:mRNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

| PRJNA1162500 | ENA

Single cell RNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

Project description:Single cell RNA sequencing analysis of fresh resected lung tissues from tuberculosis patients

| PRJNA791642 | ENA

scTCR-seq sequencing and analysis of fresh resected lung tissues from tuberculosis patients

Project description:scTCR-seq sequencing and analysis of fresh resected lung tissues from tuberculosis patients

| PRJNA1067353 | ENA

scTCR-seq sequencing and analysis of fresh resected lung tissues from tuberculosis patients

Project description:Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate that T cell exhaustion is dysfunctional in tuberculosis. Using integrated single-cell RNA sequencing and T cell receptor profiling we reported defects in exhaustion responses within inflamed tuberculosis-affected lungs. Tuberculosis lungs demonstrated significantly reduced levels of exhausted CD8+ T cells and exhibited diminished expression of exhaustion-related transcripts among clonally expanded CD4+ and CD8+ T cells. Additionally, clonal expansion of CD4+ and CD8+ T cells bearing T cell receptors specific for CMV was observed. Expanded CD8+ T cells expressed the cytolytic marker GZMK. Hence, inflamed tuberculosis-affected lungs displayed dysfunction in T cell exhaustion. Our findings likely hold implications for understanding the reactivation of tuberculosis observed in patients undergoing immunotherapy targeting the exhaustion checkpoint.

2024-09-02 | GSE253828 | GEO

MiRNA microarray analysis of 5 fresh lung cancer tissues and 5 fresh non-tumor lung tissues

Project description:MiRNA microarray analysis of 5 fresh lung cancer tissues and 5 fresh non-tumor lung tissues

| PRJNA560608 | ENA

Single cell RNA sequencing analysis of fresh resected human lung tissue

Project description:Fresh resected human lung tissue (parenchymal lung and distal airway specimens) was obtained via the CPC BioArchive at the Comprehensive Pneumology Center Munich (CPC-M, Munich, Germany) and profiled using single cell RNA sequencing technology (Drop-seq). In total, we analysed parenchymal tissue of uninvolved areas of tumour resection material from four patients.

2019-04-23 | GSE130148 | GEO

mRNAs microarray from 5 fresh lung cancer tissues and 5 fresh non-tumor tissues.

Project description:mRNAs microarray from 5 fresh lung cancer tissues and 5 fresh non-tumor tissues.

| PRJNA561095 | ENA