Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transthyrectin, a novel prognostic marker of POCD revealed by time-series RNA sequencing analysis

ABSTRACT: Transthyrectin, a novel prognostic marker of POCD revealed by time-series RNA sequencing analysis

PROVIDER: PRJNA1159782 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transthyrectin, a novel prognostic marker of POCD revealed by time-series RNA sequencing analysis

Project description:Postoperative cognitive dysfunction (POCD) is defined as a declined cognition, measured by neuropsychological tests, that persists for months or even longer after surgery. Heterogeneities in the diagnosis of POCD usually involve differences in the test batteries, the cutoffs, and the timing of assessments. Although peripheral and CSF markers of neuroinflammation have been shown to correlate with increased risk of POCD, most of them are non-specific and cannot be used for POCD diagnosis. These factors hampered the understanding of the pathogenesis of POCD as well as the development of effective preventions/treatments. In this study, we found Ttr in a panel of potential POCD biomarkers identified using time-series analysis of the transcriptomes and proteomes of the hippocampi of POCD mice that diagnosed on individual basis with composite Z-scores of test batteries consisting of Y maze and open field test. Compared with their counterparts without POCD, the levels of Ttr were significantly lower in the peripheral circulation as well as in the microglia and interstitials space in the hippocampi of the mice developed POCD at all indicated time points after surgery. Significantly lower levels of peripheral TTR were also found in human patients that displayed impaired cognition after abdominal surgeries, compared with those who did not. Endogenous expression of Ttr was verified in microglia cells both in vitro and in vivo. Results of in vitro assay indicated a potential role of Ttr in ameliorating LPS-induced microglial priming and protecting the differentiation of oligodendrocyte progenitor cells (OPCs) in proinflammatory microenvironment, which was one of the determinant factors in regulating the pathological progression of POCD.

2025-09-09 | GSE276942 | GEO

CD271/p75NTR is a novel diagnostic marker, prognostic indicator and therapeutic target in SHH medulloblastoma

Project description:The extensive heterogeneity both between and within the medulloblastoma (MB) subgroups underscores a critical need for variant-specific biomarkers and therapeutic strategies. We previously identified a role for the CD271/p75 neurotrophin receptor (p75NTR) in regulating stem/progenitor cells in the SHH MB subgroup. Here, we demonstrate the utility of CD271 as a novel diagnostic and prognostic marker for SHH MB using immunohistochemical analysis as well as transcriptome data across 763 primary tumors. Characterization of CD271+ and CD271- cells by RNA sequencing revealed that these two subpopulations are molecularly distinct, co-existing cellular subsets both in vitro and in vivo. MAPK/ERK signaling is upregulated in the CD271+ population and inhibiting this pathway reduced CD271 levels, stem/progenitor cell proliferation and cell survival as well as cell migration in vitro. Importantly, the MEK inhibitor selumetinib extends survival and reduces CD271 levels in vivo. Our study demonstrates the clinical utility of CD271 as both a diagnostic and prognostic tool for SHH MB tumors and reveals a novel role for MEK inhibitors in targeting CD271+ SHH MB cells.

2019-12-31 | GSE107701 | GEO

Eukaryote daily time series

Project description:Marine eukaryote network revealed by high frequency temporal survey in the San Pedro Ocean Time-series station

| PRJEB12215 | ENA

Daily ocean time-series

Project description:Daily ocean time-series 2011 at San Pedro Ocean time-series

| PRJEB10834 | ENA

PICO time series metagenomes

Project description:PICO time series metagenomes

| PRJNA643505 | ENA

CD271/p75NTR is a novel diagnostic marker, prognostic indicator and therapeutic target in SHH medulloblastoma

Project description:CD271/p75NTR is a novel diagnostic marker, prognostic indicator and therapeutic target in SHH medulloblastoma