Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Compound-Induced Neuroplasticity Without Immediate Early Gene Activation

ABSTRACT: Compound-Induced Neuroplasticity Without Immediate Early Gene Activation

PROVIDER: PRJNA1160299 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30648866.fastq.gz	Fastqsanger.gz
	SRR30648867.fastq.gz	Fastqsanger.gz
	SRR30648868.fastq.gz	Fastqsanger.gz
	SRR30648869.fastq.gz	Fastqsanger.gz
	SRR30648870.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Compound-Induced Neuroplasticity Without Immediate Early Gene Activation

Project description:Cortical atrophy and dysfunction are hallmarks of many neuropsychiatric diseases including depression, post-traumatic stress disorder (PTSD), and addiction. Psychoplastogens are small molecules with the potential to rapidly rescue these structural and functional deficits, leading to sustained therapeutic effects after a single administration. Classic psychedelics are among the most potent and efficacious psychoplastogens known, with recent data indicating that their clinical and preclinical effects might be more robust and durable than those of ketamine. Moreover, the advent of non-hallucinogenic psychoplastogens structurally related to psychedelics, such as tabernanthalog (TBG), has opened new opportunities for developing scalable alternatives capable of promoting structural and functional neuroplasticity in the prefrontal cortex (PFC). Currently, it is unclear what roles 5-HT2A receptors (5-HT2ARs) and immediate early gene activation play in the neuroplasticity-promoting effects of non-hallucinogenic psychoplastogens like TBG—information necessary to engineer optimized neurotherapeutics related to psychedelics. Here, we use a combination of pharmacological and genetic tools to demonstrate that several non-hallucinogenic psychoplastogens promote cortical neuron growth through the same biochemical pathway as classic psychedelics. Furthermore, we demonstrate that there is a causal relationship between TBG-induced cortical spinogenesis and its sustained antidepressant-like effects. In contrast to psychedelics, TBG promotes cortical neuron growth in the absence of a glutamate burst or immediate early gene (IEG) activation, effects assumed to be necessary for psychedelic-induced neuroplasticity. Our results elucidate how the hallucinogenic effects of psychedelics can be decoupled from their beneficial effects on cortical neuron growth.

2025-05-10 | GSE277053 | GEO

Immediate early splicing controls de novo protein synthesis after T cell activation

Project description:Immediate early genes have been known and studied for decades. Their fast and transient induction, which depends on phosphorylation cascades and is independent of de novo protein synthesis, orchestrates the cellular response to various stimuli. In this study we show that the same phosphorylation cascades also target the splicing machinery to induce an analogous splicing switch that we call immediate early splicing (IES). We characterize hnRNPC2-controlled IES, which depends on the MEK-ERK pathway and the T cell specific PKCθ. This splicing switch mainly targets components of the translation machinery and contributes to reduced de novo protein synthesis early upon T cell activation, to coordinate extensive transcriptional and posttranscriptional changes in gene expression. Together, our data set a paradigm for fast and transient alternative splicing, the immediate cellular response to activation, and provide evidence for its functional relevance during T cell activation.

2025-01-08 | GSE271051 | GEO

Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization

Project description:Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization

| PRJNA966192 | ENA

Immediate early splicing controls de novo protein synthesis after T cell activation

Project description:Immediate early splicing controls de novo protein synthesis after T cell activation

| PRJNA1129497 | ENA

Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [ThioU]

Project description:Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [ThioU]

| PRJNA966199 | ENA

Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [HLs]

Project description:Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [HLs]

| PRJNA966200 | ENA

Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [ANI]

Project description:Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [ANI]

| PRJNA752091 | ENA

Gene expression changes in rat islets with glucolipotoxic conditions with or without protective compound

Project description:To determine which GLT-regulated genes might be affected by compound D, we performed an RNA-sequencing analysis of rat islets treated ex-vivo with or without GLT and compound D for 3 hours and 24 hours. Compound E (related inactive compound) was used to account for non-specific scaffold effects.

2019-07-16 | GSE134272 | GEO

Immediate early proteins of herpes simplex virus transiently repress viral transcription before subsequent activation.

Project description:Immediate early proteins of herpes simplex virus transiently repress viral transcription before subsequent activation.

| PRJNA835718 | ENA

Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Project description:Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

| PRJNA591584 | ENA