Project description:The control or gestationally arsenic exposed F1 males (C3H strain) and C57BL/6 strain (B6) females were crossed and F2 male embryos were obtained on embryonic day 7.5 (E7.5). The DNA methylomes of the embryos were investigated by RRBS method.

2025-01-22 | GSE275185 | GEO

DNA methylation profiles of F2 mice sperm of the control group and arsenic group [sperm]

Project description:DNA methylation profiles of F2 mice sperm of the control group and arsenic group [sperm]

| PRJNA1160877 | ENA

DNA methylation profiles of F1 mice sperm of the control group and arsenic group

Project description:Pregnant C3H mice were given tap water (control group) and tap water containing 85 ppm sodium arsenite from gestational day 8 to 18 (arsenic group), respectively. The DNA methylomes of sperm of F1 mice were investigated by RRBS method. The results showed that gestational arsenic exposure increased hypomethylated cytosines in the F1 sperm genome. The present study has indicated environmental impacts on sperm DNA methylome establishment.

2020-12-08 | GSE150500 | GEO

DNA methylation profiles of F1 mice sperm of the control group and arsenic group II

Project description:Pregnant C3H mice were given tap water (control group) and tap water containing 85 ppm sodium arsenite from gestational day 8 to 18 (arsenic group), respectively. The DNA methylomes of sperm of F1 mice were investigated by RRBS method. The results showed that gestational arsenic exposure increased hypomethylated cytosines in active retrotransposon subfamilies. The present study has indicated environmental impacts on sperm DNA methylome establishment.

2020-12-08 | GSE150650 | GEO

DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group_2nd experiment

2025-01-22 | GSE275460 | GEO

Transcription profiling of rat embryonic day 16 testis RNA samples from F1, F2, F3 generation control groups vs F1, F2, F3 generation vinclozolin treated groups to examine transgenerational epigenetic programming of the embryonic testis

Project description:Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination appears to promote an epigenetic reprogramming of the male germ line that is associated with transgenerational adult-onset disease states. Transgenerational effects on the embryonic day 16 (E16) testis demonstrated reproducible changes in the testis transcriptome for multiple generations (F1-F3). The expression of 196 genes was found to be influenced, with the majority of gene expression being decreased or silenced. Dramatic changes in the gene expression of methyltransferases during gonadal sex determination were observed in the F1 and F2 vinclozolin generation (E16) embryonic testis, but the majority returned to control-generation levels by the F3 generation. The most dramatic effects were on the germ-line-associated Dnmt3A and Dnmt3L isoforms. Observations demonstrate that an embryonic exposure to vinclozolin appears to promote an epigenetic reprogramming of the male germ line that correlates with transgenerational alterations in the testis transcriptome in subsequent generations. Experiment Overall Design: E16 Testis RNA samples from F1, F2, F3 generation control groups are compared to F1, F2, F3 generation vinclozolin treated groups

2008-04-04 | E-GEOD-10919 | biostudies-arrayexpress

DNA methylation profiles of F1 mice sperm of the control group and arsenic group

Project description:DNA methylation profiles of F1 mice sperm of the control group and arsenic group

| PRJNA632597 | ENA

DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group

Project description:DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group

| PRJNA1149716 | ENA