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Melanoma derrived Short Term Cultures characterization to identify Potential targets in NF1 mutant melanoma [CUT&RUN H3K4me3]

ABSTRACT: Melanoma derrived Short Term Cultures characterization to identify Potential targets in NF1 mutant melanoma [CUT&RUN H3K4me3]

PROVIDER: PRJNA1164240 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30772108_1.fastq.gz	Fastqsanger.gz
	SRR30772108_2.fastq.gz	Fastqsanger.gz
	SRR30772109_1.fastq.gz	Fastqsanger.gz
	SRR30772109_2.fastq.gz	Fastqsanger.gz
	SRR30772110_1.fastq.gz	Fastqsanger.gz

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Melanoma derrived Short Term Cultures characterization to identify Potential targets in NF1 mutant melanoma

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NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma

Project description:The Neurofibromin 1 (NF1) tumor suppressor gene is mutated in 15-27% of melanoma patients. The overall prognosis of these patients is worse than that of patients with other genetic melanoma subtypes due to a paucity in targeted therapy options for this melanoma subtype, and its limited response to immunotherapy. Here, we compare NF1 mutant to NF1 wild melanoma using a combined multi-omics approaches of patient-derived short-term cultures (STCs) to identify potential therapeutic targets

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