Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Human glycan-sensitive antibodies protect from hepatitis E virus infection

PROVIDER: PRJNA1166121 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30818058_1.fastq.gz	Fastqsanger.gz
	SRR30818058_2.fastq.gz	Fastqsanger.gz
	SRR30818059_1.fastq.gz	Fastqsanger.gz
	SRR30818059_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Human "glycan-sensitive" antibodies protect from hepatitis E virus infection

Project description:Human "glycan-sensitive" antibodies protect from hepatitis E virus infection

| PRJEB76306 | ENA

Deciphering Mycobacterium tuberculosis glycan epitopes through clustering of human polyclonal and isolating novel monoclonal antibodies I

Project description:The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. We here used synthetic AM oligosaccharide motifs to deplete sera from subjects along the spectrum of Mtb infection. Performing cluster analysis, we were able to predict AM’s immunogenic structures and delineate how antibody reactivity to them is influenced by Mtb infection states.

2024-06-01 | GSE263496 | GEO

Deciphering Mycobacterium tuberculosis glycan epitopes through clustering of human polyclonal and isolating novel monoclonal antibodies II

Project description:The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. Through isolating and characterizing a panel of novel human mAbs with binding to distinct AM OS motifs, we further defined the glycan epitope structures, identified a new epitope, and determined their differences among mycobacterial strains.

2024-06-01 | GSE263497 | GEO

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)

Project description:Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. We investigated airway and systemic IgG, IgA, and IgM responses in paired bronchoalveolar lavage and plasma samples prior to and two- and 5-6-months post Mtb infection using an antigen-unbiased approach with Mtb glycan and proteome-wide microarrays

2024-01-10 | GSE243658 | GEO

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM30 IgM)

2024-01-10 | GSE243657 | GEO

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgG)

2024-01-10 | GSE243661 | GEO

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgA)

2024-01-10 | GSE243660 | GEO

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgG)

2024-01-10 | GSE243659 | GEO

Early and late changes in gene and miRNA expression after hepatitis B or C infection in human hepatocyte chimeric mice [tissue_miRNA]

Project description:Changes in gene and microRNA expression 10 days and 8 weeks after infection with hepatitis B and C virus and with or without interferon administration was determined in human hepatocyte chimeric mice.

2014-12-01 | GSE52750 | GEO

Early and late changes in gene and miRNA expression after hepatitis B or C infection in human hepatocyte chimeric mice [serum_miRNA]

2014-12-01 | GSE52749 | GEO