Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of rs3129882 SNP in Monocyte Chromatin Accessibility Programs

ABSTRACT: Role of rs3129882 SNP in Monocyte Chromatin Accessibility Programs

PROVIDER: PRJNA1168046 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR30861451_1.fastq.gz	Fastqsanger.gz
	SRR30861451_2.fastq.gz	Fastqsanger.gz
	SRR30861454_1.fastq.gz	Fastqsanger.gz
	SRR30861454_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 35

Similar Datasets

Role of rs3129882 SNP in Monocyte Chromatin Accessibility Programs

Project description:The rs312889 SNP is located in the MHCII locus and conferrs susceptibility to Parkinson's Disease. As the disease associated allele is non-coding, we sought to test if it was linked to epigenetic changes within the MHCII locus or more broadly in antigen presenting cells. In this study, monocytes were purified from individuals with the AA protective or GG risk alleles that were diagnosed with Parkinsons's disease or healthy. Monocytes were stimulated with IFNg for 18 hours or allowed to rest and then subjected to ATAC-seq analysis.

2025-04-10 | GSE278590 | GEO

SNP effect on chromatin accessibility (ATAC-Seq)

Project description:SNP effect on chromatin accessibility (ATAC-Seq)

| PRJNA819991 | ENA

SNP effect on chromatin accessibility (RNA-Seq)

Project description:SNP effect on chromatin accessibility (RNA-Seq)

| PRJNA819956 | ENA

SNP effect on chromatin accessibility (ChIP-Seq)

Project description:SNP effect on chromatin accessibility (ChIP-Seq)

| PRJNA820602 | ENA

Snp

Project description:Drosophila melanogaster Snp, Snipper, is differentially expressed in 12 experiment(s);

| FBgn0265192 | ExpressionAtlas

Snp

Project description:Drosophila melanogaster Snp, Snipper, is expressed in 3 baseline experiment(s);

| FBgn0265192 | ExpressionAtlas

SNP effect on chromatin accessibility (Whole genome sequencing)

Project description:SNP effect on chromatin accessibility (Whole genome sequencing)

| PRJNA693318 | ENA

Platelet-derived transcription factors license human monocyte inflammation

Project description:CD14+ monocytes, the predominant population in human blood, are primarily engaged in host defense and pro-inflammatory cytokine responses. Aberrant monocyte activity causes life-threatening cytokine storms, while dysfunctional monocytes lead to 'immunoparalysis.' Understanding the mechanisms controlling monocyte functions is therefore paramount. Here, we reveal platelets' vital role in human monocytes' pro-inflammatory responses. Natural low platelet counts in patients with immune thrombocytopenia (ITP) , platelet depletion in healthy human monocytes, or in vivo platelet depletion in mice, result in monocyte immunoparalysis, characterized by reduced pro-inflammatory gene expression and weakened cytokine responses to immune challenge. Remarkably, supplementation with fresh platelets reverses monocyte immunoparalysis. In mice, thrombocytopenia results in down-regulation of myeloid innate immune genes, and compromised host defense transcriptional programs in monocytes despite normal responses to LPS. Platelets control monocyte cytokines independently of traditional cross-talk pathways, acting as reservoirs of transcription factors like NF?B and MAPK p38. We pinpointed a vesicle-derived NF?B2 transfer to human monocytes by mass spectrometry-based proteomics. Functionally, platelets proportionally restored impaired cytokine secretion in human monocytes lacking MAPK p38a and NF?B p65 and NF?B2. We unveil the intercellular transfer of inflammatory regulators, positioning platelets as central checkpoints in monocyte-mediated inflammation.

2024-08-14 | PXD052113 | Pride

Monocyte-derived IL-6 Programs Microglia to Rebuild Damaged Brain Vasculature

Project description:Monocyte-derived IL-6 Programs Microglia to Rebuild Damaged Brain Vasculature

| PRJNA889747 | ENA

Role of TBP in chromatin accessibility (ATAC-seq)

Project description:Role of TBP in chromatin accessibility (ATAC-seq)

| PRJNA475872 | ENA