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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [ST]

ABSTRACT: Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [ST]

PROVIDER: PRJNA1168416 | ENA |

REPOSITORIES: ENA

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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [ST]

Project description:This study aims to explore the role of nerves in tumor biology, particularly focusing on their function and the impact of the neural microenvironment in cancer invasion. Utilizing multi-omics technologies, we have mapped the spatial transcriptomic landscape of nerve-associated cells in pancreatic ductal adenocarcinoma (PDAC). By analyzing tissue samples with varying degrees of neural invasion, we have uncovered the complex interactions between tumor cells, immune cells, and neurons, providing new insights into the mechanisms underlying nerve-tumor interactions. This research lays the groundwork for future studies in cancer neuroscience and potentially advances the development of novel therapeutic strategies.

2025-05-19 | GSE278687 | GEO

Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC

Project description:Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC

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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [TCR-Seq]

Project description:Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [TCR-Seq]

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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [snRNA-Seq]

Project description:Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [snRNA-Seq]

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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [scRNA-Seq]

Project description:Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [scRNA-Seq]

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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [snRNA-Seq]

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Analysis of submucosal (SM) invasion site of laterally spreading tumor among subtypes

Project description:Primary outcome(s): To clarify the pathological characteristics of submucosal(SM) invasion site and number among LST subtypes.

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Transcription profiling of pancreatic tumor cell invasion and angiogenesis in the PDAC-CAM model

Project description:Human pancreatic adenocarcinoma cells were grafted on the chick chorioallantoic membrane (CAM). Human and chicken GeneChips were used simultaneously to study gene regulation during PDAC cell invasion. Experiment Overall Design: Pooled RNA from T1 (n=3) and T6 (n=3) CAMs were extracted using the RNeasy mini kit (Qiagen). T6 was compared to T1 on human GeneChips and in parallel, on chicken GeneChips.

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