ABSTRACT: Unnoticed spread of linear VanA-plasmids in vancomycin-variable Enterococcus faecium strains across different regions: a diagnostics challenge
Project description:Characterization of vanA-harboring plasmids improves differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates
Project description:This study aims to determine the global gene expression in vancomycin resistant Enterococcus faecium (VRE) in response to a novel essential oil-vancomycin combination, and the individual components (vancomycin, carvacrol and cuminaldehyde) to help determine the mechanism of action of this antimicrobial formulation. This formulation increases the susceptibility of VRE to vancomycin and the array provides data on the synergistic mechanism of action. Five conditions (1. Control; 2. Carvacrol, 1.98 mM; 3. Cuminaldehyde, 4.20 mM; 4. Vancomycin, 0.031 mg/l; 5. Combination, 1.98 mM Carvacrol, 4.2 mM Cuminaldehyde, 0.031 mg/l vancomycin) all with 1% DMSO were tested in triplicate with a 60 minute exposure time before extraction.
Project description:Genomic surveillance of vancomycin-resistant Enterococcus faecium reveals local spread of a linear plasmid conferring a nutrient utilization advantage
Project description:Vancomycin variable Enterococcus faecium clone containing a deletion within vanX
| PRJEB25215 | ENA
Project description:Vancomycin-resistant Enterococcus faecium in Irish hospitals 2017-2019: high prevalence of ST80 and spread of very similar vanA regions via IS1216E and plasmid transfer throughout diverse genetic lineages
| PRJNA734127 | ENA
Project description:Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy
| PRJNA993974 | ENA
Project description:Sequencing of multiple Enterococcus faecium isolates from 10 patients harbouring Linear plasmids
| PRJNA1207810 | ENA
Project description:Molecular characterization of linear plasmids bearing vanA, optrA and cfr(D) genes in clinical enterococci, Italy
| PRJNA1124050 | ENA
Project description:A vanA vancomycin-resistant Enterococcus faecium ST80 outbreak resulting from a single importation event
