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BGN promotes epithelial migration in mammary gland development and breast cancer metastasis through activation of WNT signaling

ABSTRACT: BGN promotes epithelial migration in mammary gland development and breast cancer metastasis through activation of WNT signaling

PROVIDER: PRJNA1172711 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30985221.fastq.gz	Fastqsanger.gz
	SRR30985221_1.fastq.gz	Fastqsanger.gz
	SRR30985221_2.fastq.gz	Fastqsanger.gz
	SRR30985222.fastq.gz	Fastqsanger.gz
	SRR30985222_1.fastq.gz	Fastqsanger.gz

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BGN promotes epithelial migration in mammary gland development and breast cancer metastasis through activation of WNT signaling

Project description:This study investigates the role of Biglycan (BGN) in promoting epithelial migration during mammary gland development and breast cancer metastasis. Using in vitro and in vivo models, including a 3D organoid migration assay and single-cell RNA sequencing, we demonstrate that BGN enhances the interaction between WNT3A and FZD6, activating the WNT signaling pathway. This activation promotes epithelial cell migration and breast cancer metastasis. The findings provide new insights into breast cancer metastasis mechanisms and identify BGN as a potential therapeutic target.

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