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Mammary intra-epithelial lymphocytes promote lactogenesis and offspring fitness

ABSTRACT: Mammary intra-epithelial lymphocytes promote lactogenesis and offspring fitness

PROVIDER: PRJNA1175826 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32091054_1.fastq.gz	Fastqsanger.gz
	SRR32091054_2.fastq.gz	Fastqsanger.gz
	SRR32091055_1.fastq.gz	Fastqsanger.gz
	SRR32091055_2.fastq.gz	Fastqsanger.gz
	SRR32091056_1.fastq.gz	Fastqsanger.gz

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Maternal intra-epithelial lymphocytes support lactogenesis and offspring fitness

Project description:Maternal intra-epithelial lymphocytes support lactogenesis and offspring fitness

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Mammary intra-epithelial lymphocytes promote lactogenesis and offspring fitness

Project description:Breastfeeding is an obligatory requirement of mammalian survival. This fundamental process is associated with the adaptation of maternal physiology including the transformation of the mammary gland into a milk-secreting organ. How maternal immunity contributes to mammary gland remodeling and function remains largely unknown. Here, we show that maternal adaptive immunity plays a critical role in shaping lactogenesis. Specifically, physiological adaptation during pregnancy is associated with thymic involution and a paradoxical enrichment in intraepithelial lymphocyte (IEL) precursors that no longer migrate to the gut, but instead preferentially accumulate within the mammary gland. Within this compartment, IEL precursors differentiate into T-bet-expressing unconventional CD8 lymphocytes with a cytotoxic signature which accumulate within the mammary epithelium in an IL-15-dependent manner. Mammary intra-epithelial lymphocytes control milk production by favoring differentiation and maturation of both contractile and milk-secreting cells, thereby promoting offspring fitness. Altogether, this work uncovers a previously unappreciated contribution of the maternal adaptive immune system in organismal remodeling during pregnancy that is associated with mammary gland development and function.

2025-06-04 | GSE280020 | GEO

Maternal intra-epithelial lymphocytes support lactogenesis and offspring fitness

Project description:Breastfeeding is an obligatory requirement of mammalian survival. This fundamental process is associated with the remodeling of maternal physiology including the transformation of mammary gland into milk-secreting organ. While adaptive immunity has been associated with the broad control of host physiology, how maternal immunity contributes to organismal remodeling during pregnancy including mammary gland remodeling and function remains largely unknown. Here, we show that maternal adaptive immunity plays a critical role in shaping lactogenesis. Specifically, physiological adaptation to pregnancy is associated with thymic involution and paradoxical enrichment in intraepithelial lymphocyte precursors that no longer migrate to the gut but preferentially accumulate within the mammary gland. Within this compartment the precursors develop as T-bet expressing lymphocytes accumulating within the mammary epithelium in an IL-15 dependent manner. Mammary intra-epithelial lymphocytes control milk production by favoring differentiation of both contractile and milk-secreting cells, thereby affecting offspring fitness. Altogether, this work uncovers a previously unappreciated contribution of the maternal adaptive immune system in organismal remodeling during pregnancy associated with mammary gland development and function.

2025-02-14 | GSE253989 | GEO

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Project description:Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

| PRJNA1173726 | ENA

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Project description:Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

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Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Project description:To test the role of intraepithelial lymphocytes in mammay grand epithelial function during pregnancy we performed single cell RNA sequencing of epithelial and myoepithelial cells from the mammary gland in WT mice, Raggc-KO mice, Raggc-KO mice adaptively transferred with IEL precursors.

2025-02-14 | GSE279628 | GEO

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness

Project description:T cells accumulate in the mammary gland during pregnancy and lactation. In order to understand the diversity, transcriptional states, TCR repertoire, and function of mammary gland T cells, and how these change during pregnancy and lactation compared to homeostasis, we performed single cell RNA sequencing on mammary gland T cells in mice.

2025-02-14 | GSE279627 | GEO

Paternal microbiome and offspring fitness.

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Paternal microbiome perturbations impact offspring fitness

Project description:<p>The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, the systemic impact of the gut microbiome on the germline - and consequently on the F1 offspring it gives rise to - is unexplored. Here we show that the gut microbiota act as a key interface between paternal preconception environment and intergenerational health in mice. Perturbations to the gut microbiota of prospective fathers increase the probability of their offspring presenting with low birth weight, severe growth restriction and premature mortality. Transmission of disease risk occurs via the germline and is provoked by pervasive gut microbiome perturbations, including non-absorbable antibiotics or osmotic laxatives, but is rescued by restoring the paternal microbiota before conception. This effect is linked with a dynamic response to induced dysbiosis in the male reproductive system, including impaired leptin signalling, altered testicular metabolite profiles and remapped small RNA payloads in sperm. As a result, dysbiotic fathers trigger an elevated risk of in utero placental insufficiency, revealing a placental origin of mammalian intergenerational effects. Our study defines a regulatory ‘gut-germline axis’ in males, which is sensitive to environmental exposures and programs offspring fitness through impacting placental function.</p>

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Maternally infection promotes offspring tissue-specific immune fitness

Project description:Maternally infection promotes offspring tissue-specific immune fitness

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