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In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [array]

ABSTRACT: In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [array]

PROVIDER: PRJNA1176627 | ENA |

REPOSITORIES: ENA

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In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [array]

Project description:In vitro fertilization (IVF) is a non-coital method of conception used to treat infertility. Although safe, IVF has been associated with adverse outcomes in the fetus, placenta, and adult life, but studies focusing on the male reproductive system are limited. Here, we used a mouse model to assess the morphological and molecular effects of IVF on male offspring. We evaluated three developmental stages: 18.5-day fetuses and 12- and 39-week adults. Regardless of age, we observed changes in the testicular-to-body weight ratio, serum testosterone levels, testicular morphology, transcriptome, and DNA methylation. Also, sperm showed changes in morphology and DNA methylation. To assess multigenerational phenotypes, we mated IVF and naturally conceived males with wild-type females. Offspring from IVF males exhibited a decreased fetal weight-to-placental weight ratio regardless of sex. At 12-weeks-of-age, offspring showed higher body weights, differences in glucose, triglycerides, insulin, total cholesterol, HDL and LDL/VLDL levels. Both sexes showed changes in gene expression in liver, testes and ovaries, and decreased global DNA methylation. Collectively, our findings demonstrate that male IVF offspring exhibit abnormal testicular and sperm morphology and molecular alterations and transmit defects multigenerationally. These experiments contribute to our understanding of the long-term impacts of IVF on adult offspring health.

2025-03-31 | GSE280162 | GEO

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-Seq]

2025-03-31 | GSE280285 | GEO

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-seq II]

2025-03-31 | GSE290562 | GEO

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

Project description:In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

| PRJNA1177752 | ENA

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-Seq]

Project description:In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-Seq]

| PRJNA1177755 | ENA

Mouse Offspring Conceived by In Vitro Fertilization Exhibit Accelerated Reproductive Aging Through Early Ovarian Failure

Project description:In vitro fertilization (IVF) is an assisted reproductive technology that has enabled millions of births. Although considered safe, emerging evidence suggests that IVF may have long-term health adverse outcomes in offspring, though its impact on female reproduction, especially on reproductive aging is largely unknown. Here, we use a mouse model to investigate how IVF influences female reproductive and transgenerational health outcomes. We assessed IVF-conceived fetal (E18.5) and adult (12-week and 39-week) female offspring, identifying alterations in ovarian-to-body weight ratios, ovarian morphology, serum sex hormone levels, and transcriptomic and DNA methylation profiles in ovaries, oocytes, and cumulus cells, consistent with biomarkers of accelerated reproductive aging. The offspring of IVF females and wild-type males exhibited altered fetal-to-placental weight ratios, placental morphology, and dysregulated placental gene expression. At 12-weeks-of-age, offspring showed increased body weight, disrupted lipid and glucose metabolism, and transcriptomic and epigenetic changes in liver and reproductive organs. Our results highlight the need for deeper mechanistic understanding of assisted reproduction’s long-term and multigenerational impacts on female reproductive health.

2026-01-29 | GSE307881 | GEO

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-seq II]

Project description:In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-seq II]

| PRJNA1228628 | ENA

In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects.

Project description: Not available

| S-EPMC12016927 | biostudies-literature

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-31 | GSE280286 | GEO

Mouse Offspring Conceived by In Vitro Fertilization Exhibit Accelerated Reproductive Aging Through Early Ovarian Failure

Project description:Mouse Offspring Conceived by In Vitro Fertilization Exhibit Accelerated Reproductive Aging Through Early Ovarian Failure