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Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

ABSTRACT: Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

PROVIDER: PRJNA1177796 | ENA |

REPOSITORIES: ENA

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Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

Project description:Radiation-induced brain injury (RIBI) is a series of brain injuries caused by exposure to high doses of ionizing radiation, characterized by severe cognitive dysfunctions and brain necrosis.In this study, we described a biomimetic human blood-brain barrier (BBB) model that allowed to probe the responses to radiation exposure.This RNA-seq data illustrated that representative RIBI-associated pathological responses including BBB compromise, DNA break, inhibited cell proliferation, cell swelling and release of pro-inflammatory cytokines following acute radiation exposure. Based on the pathogenic mechanism study, we carried out drug screening and identified two drugs effectively ameliorated radiation-induced inflammation and BBB injury on the BBB model. Collectively, the study uncovered an unknown mitochondria-mediated inflammation involved in the pathogenesis of RIBI, indicating mitochondria can be utilized as a potential target for developing new radioprotective measures.

2025-09-03 | GSE280304 | GEO

Radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

Project description:Radiation-induced brain injury (RIBI) is a series of brain injuries caused by exposure to high doses of ionizing radiation, characterized by severe cognitive dysfunctions and brain necrosis.In this study, we described a biomimetic human blood-brain barrier (BBB) model that allowed to probe the responses to radiation exposure.This RNA-seq data illustrated that representative RIBI-associated pathological responses including BBB compromise, DNA break, inhibited cell proliferation, cell swelling and release of pro-inflammatory cytokines following acute radiation exposure. Collectively, the study uncovered an unknown mitochondria-mediated inflammation involved in the pathogenesis of RIBI, indicating mitochondria can be utilized as a potential target for developing new radioprotective measures.

2025-09-03 | GSE280303 | GEO

Radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

Project description:Radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation

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Zebrafish BBB transcriptome

Project description:Zebrafish BBB transcriptome

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Gene expression data of BBB and BCB two-cell embryos

Project description:We constructed one-cell stage embryos by maternal pronuclear (mPN) transfer having B6 ooplasm, B6 paternal PN (pPN), and either B6 or C3H mPN (BBB and BCB, respectively). We collected embryos of each type that were either treated (BBB+a, BCB+a) or untreated with Î±-amanitin (BBB, BCB) at the two-cell stage for microarray analysis. Comparison of the transcriptomes of these different kinds of embryos revealed genes for which expression differs according to maternal PN strain of origin, and the Î±-amanitin data revealed which of these differences is due to gene transcription, as opposed to any transcription-independent differences attributable to ooplasm-derived maternal mRNA pools. There are 4 replicates for each kind/treatment two-cell embryos (BBB, BCB, BBB+a, BCB+a).

2010-03-22 | E-GEOD-17886 | biostudies-arrayexpress

Transcriptome analysis after BBB-EC migration

Project description:A monolayer of hCMEC/D3 (BBB-EC) was grown in an insert. After reaching confluency, BBB-EC were treated with TNFa and IFNg for 24h. Next, BBB-EC were washed. Tregs were isolated from human blood (both healthy donors (HD)and untreated RRMS patients) and added to the upper chamber of the insert or were cultured in the BBB-EC medium as control (untouched_1). They were let to migrate for 24h and the upper fraction (non-migrated_2) and lower fraction (migrated_3) were collected.

2024-02-11 | GSE255171 | GEO

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

Project description:The blood-brain barrier (BBB) protects the central nervous system (CNS) from external assaults by pathogenic or harmful substances. BBB impairment frequently occurs during infection, inflammatory, or other pathological conditions, which causes or exacerbates a wide range of CNS diseases. Using single cell transcriptomics, we show in this study that during systemic LPS challenges, brain endothelial cells undergo Gsdmd-mediated pyroptosis and impair the integrity of the BBB, leading to profound changes in the transcriptomic landscape of brain parenchymal populations. Analyses of the scRNA-seq dataset reveal that brain endothelial cells responded strongly to systemic LPS challenge. Further analyses of the transcriptional signatures revealed that the brain parenchymal populations displayed heterogeneous responses to BBB leakage accompanied by systemic inflammation.

2024-02-22 | GSE211099 | GEO

Burkholderia gladioli strain:BBB-01

Project description:Burkholderia gladioli strain:BBB-01 Genome sequencing

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Transcriptome analysis after BBB-EC migration

Project description:Transcriptome analysis after BBB-EC migration

| PRJNA1073892 | ENA

Gene expression data of BBB and BCB two-cell embryos

Project description:We constructed one-cell stage embryos by maternal pronuclear (mPN) transfer having B6 ooplasm, B6 paternal PN (pPN), and either B6 or C3H mPN (BBB and BCB, respectively). We collected embryos of each type that were either treated (BBB+a, BCB+a) or untreated with α-amanitin (BBB, BCB) at the two-cell stage for microarray analysis. Comparison of the transcriptomes of these different kinds of embryos revealed genes for which expression differs according to maternal PN strain of origin, and the α-amanitin data revealed which of these differences is due to gene transcription, as opposed to any transcription-independent differences attributable to ooplasm-derived maternal mRNA pools.

2010-03-22 | GSE17886 | GEO

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