Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Effects of bile acid (BA) supplementation on the lipid metabolism in high-fat diet fed spotted sea bass (Lateolabrax maculatus)

PROVIDER: PRJNA1180132 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31176514_1.fastq.gz	Fastqsanger.gz
	SRR31176514_2.fastq.gz	Fastqsanger.gz
	SRR31176515_1.fastq.gz	Fastqsanger.gz
	SRR31176515_2.fastq.gz	Fastqsanger.gz
	SRR31176516_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Project description:Transcriptome of spotted sea bass (Lateolabrax maculatus) under hypoxia

| PRJNA1445396 | ENA

Project description:Transcriptome of spotted sea bass (Lateolabrax maculatus) under high temperature

| PRJNA1447087 | ENA

Project description:RNA-seq of spleen tissue in spotted sea bass(Lateolabrax maculatus)

| PRJNA657945 | ENA

Project description:RNA-seq of spotted sea bass (Lateolabrax maculatus) infected with Aeromonas veronii

| PRJNA755166 | ENA

Multicomponent Parenteral Lipid Emulsions Do Not Protect Against Liver Injury in Neonatal Pigs with Obstructive Cholestasis

Project description:Biliary atresia (BA) is a pediatric liver disease that often necessitates parenteral nutrition (PN) to support growth due to impaired liver function. While soy oil lipid emulsions (SLE) are commonly used in PN, they may contribute to cholestatic liver injury. In contrast, mixed oil lipid emulsions (MLE) have shown promise in preventing cholestasis in non-BA infants, potentially by restoring bile flow. However, their effectiveness in cases of complete bile duct obstruction, as seen in BA, remains uncertain. To explore the potential benefits of MLE in BA, we utilized a neonatal pig model of bile duct ligation (BDL). Pigs underwent either BDL or sham surgery and were subsequently fed either MLE or SLE via PN, or enterally with formula. The MLE-BDL pigs exhibited significantly greater weight gain compared to those fed SLE or formula enterally. Additionally, MLE-BDL pigs showed higher serum bile acid and gamma-glutamyl transferase concentrations compared to SLE-BDL pigs. However, no significant differences in liver injury, assessed by ductular reaction or fibrosis, were observed between MLE- and SLE-BDL pigs. Based on weight gain alone, MLE may be a superior lipid emulsion for use in neonates with obstructive cholestasis.

2025-06-16 | GSE281589 | GEO

Project description:Transcriptome analysis of immune response against Edwardsiella tarda infection in spotted sea bass (Lateolabrax maculatus)

| PRJNA1229114 | ENA

Quercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.

Project description:Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabolism in mice with diet induced body weight gain and hepatic lipid accumulation. Adult male mice received a high-fat diet without or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Body weight gain was 29% lower in quercetin-fed mice (p<0.01), while the energy intake was not significantly different. Quercetin supplementation reduced hepatic lipid accumulation with 71% (p<0.05). 1H nuclear magnetic resonance serum lipid profiling revealed that the supplementation lowered serum lipids (p<0.0001). Global gene expression profiling of liver showed that key target genes of the transcription factor Constitutive androstane receptor (Car; official symbol Nr1i3) were regulated, in particular Cytochrome P450 2b (Cyp2b) genes. Quercetin can decrease high-fat diet induced body weight gain, hepatic lipid accumulation and serum lipid levels, which might be explained by the regulation of Cytochrome P450 genes under transcriptional control of CAR, an effect which is likely dependent on dietary background. Liver samples were obtained from 24 C57BL/6J male adult mice. All mice started with a three week adaptation phase, in which they were fed a normal-fat diet. During the intervention of 12 weeks, the mice received a high-fat diet without (HF) or with supplementation of 0.33% (w/w) quercetin (HF-Q). Based on visual inspection, three arrays lacked homogenous hybridization and were therefore excluded.

2014-10-14 | E-GEOD-51343 | biostudies-arrayexpress

Project description:Transcriptome sequencing of the spleen of the Spotted Sea Bass (Lateolabrax maculatus) after Nocardia seriolae infection

| PRJNA1093234 | ENA

Project description:Lateolabrax maculatus

| PRJNA1417260 | ENA

Project description:Lateolabrax maculatus

| PRJNA1437891 | ENA