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FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [RNA]

ABSTRACT: FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [RNA]

PROVIDER: PRJNA1180459 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31179174_1.fastq.gz	Fastqsanger.gz
	SRR31179174_2.fastq.gz	Fastqsanger.gz
	SRR31179175_1.fastq.gz	Fastqsanger.gz
	SRR31179175_2.fastq.gz	Fastqsanger.gz
	SRR31179176_1.fastq.gz	Fastqsanger.gz

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FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ChIP]

Project description:Proper development of surface epithelium (SE) is a requisite for the normal development and function of ectodermal appendages; however, the molecular mechanisms underlying SE commitment remain largely unexplored. Here, we developed a KRT8 reporter system and utilized it to identify FOXO4 and SP6 as novel, essential regulators governing SE commitment. We found that the FOXO4-SP6 axis governs SE fate and its abrogation markedly impedes SE fate determination. Mechanistically, FOXO4 regulates SE initiation by shaping the SE chromatin accessibility landscape and regulating the deposition of H3K4me3. SP6, as a novel effector of FOXO4, activated SE-specific genes through modulating the H3K27ac deposition across their super enhancers. Our work highlights the regulatory function of the FOXO4-SP6 axis in SE development, contributing to an improved understanding of SE fate decisions and providing a research foundation for the therapeutic application of ectodermal dysplasia.

2025-05-22 | GSE280746 | GEO

FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ATAC]

2025-05-22 | GSE280745 | GEO

FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [RNA]

2025-05-22 | GSE280747 | GEO

FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ATAC]

Project description:FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ATAC]

| PRJNA1180452 | ENA

FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ChIP]

Project description:FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling [ChIP]

| PRJNA1180456 | ENA

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]

Project description:AKT1 is a serine/threonine kinase implicated in fetal, placental, and postnatal growth. In this study, we investigated roles for AKT1 in placental development using a genome-edited/loss-of-function rat model. Both heterozygous and homozygous Akt1 mutant rats were viable and fertile. Disruption of AKT1 resulted in placental, fetal, and postnatal growth restriction. Akt1 null placentas showed deficits in both junctional zone and labyrinth zone size and their ability to adapt to a physiological stressor. Robust differences in the transcriptome of wild type versus Akt1 null junctional zones were identified. Among the differentially expressed junctional zone transcripts was forkhead box O4 (Foxo4), which encodes a transcription factor and known AKT substrate. FOXO4 expression was prominent in the junctional zone and invasive trophoblast cells of the rat placentation site and enhanced following rat TS cell differentiation. Foxo4 gene disruption using genome-editing resulted in placentomegaly, including an enlarged junctional zone. AKT1 and FOXO4 regulate the expression of many of the same transcripts expressed by trophoblast cells; however, in opposite directions. In summary, we have identified AKT1 and FOXO4 as part of a regulatory network controlling hemochorial placenta development.

2023-01-05 | GSE205829 | GEO

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

2023-01-05 | GSE205828 | GEO

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

Project description:AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

| PRJNA847913 | ENA

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]

Project description:AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]

| PRJNA847912 | ENA

Genome-wide Analysis of Sp6/Epiprofin DNA Binding Sites in the Developing Mouse Molar Using ChIP-seq Analysis

Project description:In this study, whole-genome ChIP-seq analysis was performed to identify Sp6 regulatory targets from postnatal mouse molars. Enriched sequence reads (peaks) from Sp6 immunoprecipitations were located predominately adjacent to transcriptional start sites. Notably enriched for Sp6 peaks were genes highly-expressed in the tooth. Bioinformatic analysis of two pools of 1400 Sp6 enriched sequences identified a consensus nine-nucleotide DNA pulldown sequence of CTg/aTAATTA from mesenchyme and the nearly identical sequence, CTa/gTAATTA, from epithelium. Sp6 AT-rich interaction sequences are nearly identical to the ChIP-seq enriched sequences reported for Sp7 and Sp9. ChIP-seq analysis indicates Sp6 regulates a significant number of genes expressed in the tooth. GSE145909 is the original submission. GSE151391 is also from the same study. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE151391

2021-11-23 | GSE145909 | GEO

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