Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nuleus RNA-sequencing of septal cells during postnatal development

ABSTRACT: Single-nuleus RNA-sequencing of septal cells during postnatal development

PROVIDER: PRJNA1185620 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31326100.fastq.gz	Fastqsanger.gz
	SRR31326101.fastq.gz	Fastqsanger.gz
	SRR31326102.fastq.gz	Fastqsanger.gz
	SRR31326103.fastq.gz	Fastqsanger.gz
	SRR31326104.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 96

Similar Datasets

mRNA profiles of livers during postnatal development

Project description:mRNA profiles of livers during postnatal development

| PRJNA944575 | ENA

Single-nuleus RNA-sequencing of septal cells during postnatal development

Project description:Purpose: The goal of this study is to use snRNA-seq to identify the diversity of cell types derived from Nkx2.1 lineage and non-Nkx2.1 lineages in the postnatal developing septum, and examine the cell trajectories, especially glial cells in the develping septum; Methods: The septum of P0, P3, P7,P14,P21 Nkx2.1Cre;SunGFP were collected, and nuclei of the septum cells were isolated, then GFP+ and GFP- nuclei were sorted out and followed by 10X genomics sequencing; Results: we found diversity of astrocytes in the septum based on unique molecular profiles which follows the lineage separation, and we also observed the distinct developmental trajectories of subpopulation of astrocytes.

2025-04-13 | GSE281738 | GEO

Single-cell spatiotemporal transcriptome dynamics of mouse prefrontal cortex intratelencephalic neurons during postnatal development

Project description:The prefrontal cortex (PFC) is a core regulatory center for higher cognitive functions in the mammalian brain. In early postnatal mice, the PFC remains incompletely mature, particularly the intratelencephalic (IT) neurons located in superficial layers. However, the molecular developmental trajectories and regulatory mechanisms of IT neurons during the critical postnatal period (1-2 weeks) for circuit establishment, remain poorly characterized at single-cell resolution. Here, we performed single-cell RNA sequencing analysis on mouse PFC isolated at different developmental time points, and integrated with spatial transcriptomic data. Our study systematically deciphered the spatiotemporal transcriptome dynamics of mouse PFC during postnatal development, with particular emphasis on the heterogeneity of IT neurons. We identified dynamically expressed genes during postnatal development, including cadherin and axon guidance molecule genes, as well as specific transcriptional regulators that control the maturation of IT neurons in different layers. Furthermore, we also revealed that glial cells play crucial regulatory roles in IT neuron development through specific signaling pathways. Our study provides a comprehensive single-cell atlas of postnatal mouse PFC development, offering important insights into the mechanisms of neural development and circuit assembly in PFC.

2025-05-28 | GSE298260 | GEO

Gene expression changes during primate postnatal brain development

Project description:Gene expression changes during primate postnatal brain development

| PRJNA106343 | ENA

single nucleus RNA-seq for mice septal area

Project description:To characteirze the cell types in the septal area of mice using single nuclues RNA-seq

2024-07-02 | GSE248697 | GEO

Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development

Project description:We performed a large-scale single cell transcriptomic (scRNA-seq) and epigenomic (snATAC-seq) characterization of cellular subtypes (adipose stromal cells (ASC) and adipocyte nuclei) during inguinal WAT (subcutaneous; iWAT) development in mice, capturing the early postnatal period (postnatal days (PND) 06 and 18) through adulthood (PND56).

2021-09-08 | GSE180589 | GEO

Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development

Project description:Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development

| PRJNA545740 | ENA

Hedgehog and PDGF signaling intersect during postnatal lung development

Project description:Hedgehog and PDGF signaling intersect during postnatal lung development

| PRJNA853385 | ENA

Molecular profiling of mouse septal neurons with single nucleus RNA-seq

Project description:To reveal functional diversity of neurons in the septal area of the forebrain, we isolated neuron nuclei from septal tissues of wild-type mice by FACS sorting and subjected them to single nucleus (sn)RNA sequencing with the 10x platform.

2024-09-23 | GSE193890 | GEO

Single-Cell RNA-seq of Postnatal Development of Cardiomyocyte

Project description:Single-Cell RNA-seq of Postnatal Development of Cardiomyocyte

| PRJNA658096 | ENA