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Exosome-like nanovesicles from Peucedanum japonicum directly regulate inflammatory cytokines via small RNAs

ABSTRACT: Exosome-like nanovesicles from Peucedanum japonicum directly regulate inflammatory cytokines via small RNAs

PROVIDER: PRJNA1186696 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31363264_1.fastq.gz	Fastqsanger.gz
	SRR31363264_2.fastq.gz	Fastqsanger.gz
	SRR31363265_1.fastq.gz	Fastqsanger.gz
	SRR31363265_2.fastq.gz	Fastqsanger.gz
	SRR31363266_1.fastq.gz	Fastqsanger.gz

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Exosome-like nanovesicles from Peucedanum japonicum directly regulate inflammatory cytokines via small RNAs

Project description:Inflammation plays a key role in the pathogenesis of various diseases, including inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Similar to animals, plant cells produce exosome-like nanovesicles (ELNs) that play a role in transmitting biological signals from specific types of cells or tissues to other cells or tissues. Here we show that ELNs derived from Peucedanum japonicum (PjELNs) exhibit potent anti-inflammatory effects on macrophages and are effective in a mouse colitis model induced by dextran sodium sulfate (DSS). RNA sequence analysis reveals that PjELNs suppress multiple inflammatory cytokine-mediated signaling pathways in LPS-stimulated macrophage cell lines. We further show that PjENLs promote the differentiation of goblet cells, thereby enhancing mucin production and providing a protective effect on mucosal damage in a DSS-induced murine model of colitis. We also demonstrate that PjELNs inhibit the DSS-induced reduction in the number of transit amplifying cells. PjELNs exhibit anti-inflammatory properties, partly due to the presence of miRNA-like small RNAs that directly regulate the expression of the inflammatory cytokine IL6. Importantly, these small RNAs exhibit cross-species effects in both humans and mice. These findings reveal the mechanism by which plant-derived ELNs modulate inflammatory responses, suggesting their potential as a preventive and therapeutic strategy for inflammatory diseases of the colon.

2025-06-19 | GSE282037 | GEO

Small RNAs in Exosome-like nanovesicles from Peucedanum japonicum (PjELNs)

2025-06-19 | GSE282146 | GEO

Small RNAs in Exosome-like nanovesicles from Peucedanum japonicum (PjELNs)

Project description:Small RNAs in Exosome-like nanovesicles from Peucedanum japonicum (PjELNs)

| PRJNA1187462 | ENA

Peucedanum japonicum

Project description:Peucedanum japonicum overview

| PRJNA1280218 | ENA

Exosome-like nanovesicles from Peucedanum Japonicum directly regulate inflammatory cytokines via small RNAs.

Project description: Not available

| S-EPMC12304193 | biostudies-literature

S. japonicum exosome-like vesicles LC-MS/MS

Project description:Secreted extracellular vesicles play an important role in pathogen-host interactions. Increased knowledge of schistosome extracellular vesicles could provide insights into schistosome-host interactions and enable the development of novel intervention strategies to inhibit parasitic processes and lessen disease transmission. Here, we describe biochemical characterization of Schistosoma japonicum exosome-like vesicles (S. japonicum EVs) by LC-MS/MS

2018-10-27 | PXD003364 | Pride

Peucedanum dissolutum Peucedanum guangxiense Peucedanum longshengense Peucedanum mashanense Peucedanum nanum Peucedanum pubescens Peucedanum shanianum Peucedanum wawrae Peucedanum wulongense

Project description:Peucedanum dissolutum Peucedanum guangxiense Peucedanum longshengense Peucedanum mashanense Peucedanum nanum Peucedanum pubescens Peucedanum shanianum Peucedanum wawrae Peucedanum wulongense Raw sequence reads

| PRJNA1030507 | ENA

LC-MS lipidomic characterization of plant-derived exosome-like nanovesicles from ginseng, pueraria lobata, and Chinese yam

Project description:<p>This study characterizes the lipid composition of exosome-like nanovesicles isolated from Ginseng, Pueraria lobata, and Chinese yam using LC-MS-based lipidomics. The dataset includes LC-MS raw data and processed lipid annotation and relative quantification tables acquired in both positive and negative ionization modes. The primary objective was to identify lipid species, characterize lipid categories, and describe the relative lipid profiles of nanovesicles derived from different plant sources. These data are mainly suitable for lipid identification, lipid-class profiling, and relative quantification, but are not intended for statistical differential analysis between groups.</p>

2026-07-27 | MTBLS14935 | MetaboLights

Lipidomics profiling of winter melon (Benincasa hispida) exosome-like nanovesicles

Project description:This project provides comprehensive untargeted lipidomics profiling data of fresh winter melon (Benincasa hispida) exosome-like nanovesicles

| PXD079485 |

Hippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism

Project description:Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect against dexamethasone-induced muscle wasting. HR-ELNs isolated by sucrose density gradient ultracentrifugation exhibited nanoscale vesicular morphology and carried a metabolite-rich cargo. In C2C12 cells, HR-ELNs were rapidly internalized and localized predominantly in the cytoplasm, where they counteracted dexamethasone-induced upregulation of Atrogin-1 and MuRF1, downregulation of MyoG, and reduction of MyHC-positive myotube area. In a dexamethasone-induced sarcopenia mouse model, intramuscular HR-ELN administration improved grip strength and treadmill endurance while attenuating the increase in body fat content. Multi-omics profiling of skeletal muscle revealed coordinated transcriptomic and proteomic remodeling after HR-ELN treatment, with convergent enrichment of lipid metabolism, fatty acid degradation, AMPK signaling and PPAR-related pathways. Histological analyses further supported reduced lipid deposition and altered PPAR immunoreactivity in gastrocnemius muscle. Together, these findings identify HR-ELNs as bioactive plant-derived nanovesicles that couple anti-atrophic and metabolic effects, and suggest a natural nanotherapeutic strategy for glucocorticoid-associated skeletal muscle dysfunction.

2026-07-17 | MTBLS15070 | MetaboLights

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