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Sp140L Is a Herpesvirus Restriction Factor [scRNA-seq]

ABSTRACT: Sp140L Is a Herpesvirus Restriction Factor [scRNA-seq]

PROVIDER: PRJNA1188499 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31408046.fastq.gz	Fastqsanger.gz
	SRR31408047.fastq.gz	Fastqsanger.gz
	SRR31408048.fastq.gz	Fastqsanger.gz
	SRR31408049.fastq.gz	Fastqsanger.gz
	SRR31408050.fastq.gz	Fastqsanger.gz

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Sp140L Is a Herpesvirus Restriction Factor [scRNA-seq]

Project description:Herpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA sensing mechanisms to drive infection and pathogenesis. The first viral latency protein expressed, EBNA-LP, is essential for the transformation of naïve B cells, yet its role in evading host defenses remains unclear. Using single-cell RNA sequencing of EBNA-LP-Knockout (LPKO)-infected B cells, we reveal an antiviral response landscape implicating the ‘speckled proteins’ as key restriction factors countered by EBNA-LP. Specifically, loss of SP100 or the primate-specific SP140L reverses the restriction of LPKO, suppresses a subset of canonically interferon-stimulated genes, and restores viral gene transcription and cellular proliferation. Notably, we also identify Sp140L as a restriction target of the herpesvirus saimiri ORF3 protein, implying a role in immunity to other DNA viruses. This study reveals Sp140L as a restriction factor that we propose links sensing and transcriptional suppression of viral DNA to an IFN-independent innate immune response, likely relevant to all nuclear DNA viruses.

2024-11-20 | GSE282400 | GEO

Sp140L Is a Herpesvirus Restriction Factor [Day5_LPKO_vs_SP100_SP140L_KO_BulkRNAseq]

Project description:Sp140L Is a Herpesvirus Restriction Factor [Day5_LPKO_vs_SP100_SP140L_KO_BulkRNAseq]

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Sp140L Is a Herpesvirus Restriction Factor [Day8_WT_vs_LPKO_BulkRNAseq]

Project description:Sp140L Is a Herpesvirus Restriction Factor [Day8_WT_vs_LPKO_BulkRNAseq]

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Sp140L Is a Herpesvirus Restriction Factor [Day5_LPKO_vs_SP100_SP140L_KO_BulkRNAseq]

2024-11-20 | GSE282377 | GEO

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