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Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST CLI-BioLINCC)

ABSTRACT: Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST CLI-BioLINCC)

PROVIDER: PRJNA1189188 | ENA |

REPOSITORIES: ENA

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Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST CLI-BioLINCC)

Project description:Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST CLI-BioLINCC)

| PRJNA1189189 | ENA

Long-term changes following pre-conditioned circulating angiogenic cells therapy in critical limb ischemia

Project description:Critical limb ischemia (CLI), results from a severe blockade of the arterial vessels, is usually correlated to atherosclerosis. Circulating angiogenic cells (CACs) constitute a good alternative as CLI cell therapy due to their vascular regenerative potential, although the mechanisms of action of these cells as well as their response to pathological conditions remains unclear. Previously, we have shown that the incubation ex vivo of CACs with factors secreted by atheroma plaques promotes the activation and mobilization of these cells. Herein, we have evaluated the long-term effect of CACs administration in CLI mice, whether pre-stimulated or not with atherosclerotic factors.

2022-02-16 | PXD024132 | Pride

Identification of the initial molecular changes in response to Circulating Angiogenic Cells-mediated therapy in Critical Limb Ischemia

Project description:Circulating angiogenic cells (CACs) constitute promising candidates for cell therapy in critical limb ischemia (CLI) due to their assigned vascular regenerative properties. A label free MS-based quantitative approach was performed to identify protein changes related. We analyzed the initial molecular mechanisms triggered by human CACs after being administered to a murine model of CLI, in order to understand how these cells promote angiogenesis within the ischemic tissue.

2020-05-27 | PXD017661 | Pride

mRNA expression profile of Tie2 monocytes in limb ischemia patients and controls

Project description:Tie2-expressing monocytes do not appear to effect revascularisation in critical limb ischemia (CLI) patients, despite a large body of evidence demonstrating their pro-angiogenic potential when isolated from control patients. In order to understand what might cause this loss of angiogenic function, we carried out a whole genome microarray analysis of mRNA isolated from Tie2-expressing monocytes from CLI patients and compared that with age-matched control samples. 12 samples in total

2016-07-21 | E-GEOD-84626 | biostudies-arrayexpress

mRNA expression profile of Tie2 monocytes in limb ischemia patients and controls

2016-07-21 | GSE84626 | GEO

Broccoli Sprouts Extracts Trial (BEST-COPD-BioLINCC)

Project description:Broccoli Sprouts Extracts Trial (BEST-COPD-BioLINCC)

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Broccoli Sprouts Extracts Trial (BEST-COPD-BioLINCC)

Project description:Broccoli Sprouts Extracts Trial (BEST-COPD-BioLINCC)

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