Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense and regulation

ABSTRACT: Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense and regulation

PROVIDER: PRJNA1190499 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31509850.fastq.gz	Fastqsanger.gz

Items per page:

1 - 1 of 1

Similar Datasets

Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense and regulation

Project description:Decidual NK cells (dNK) are key immune effector cells at the maternal-fetal interface. dNK utilize the anti-microbial peptide granulysin (GNLY) to kill pathogens, without killing trophoblast cells. Since rodents lack the GNLY gene, the in vivo biology of GNLY expression by dNK and their control of microbes is not well-understood. Here we defined dNK GNLY expression in placental membranes of Rhesus macaques and humans. GNLY-high dNK of both species shared conserved transcriptional and protein signatures of anti-microbial defense and immunoregulation. In addition, both human and rhesus GNLY-high dNK responded to inflammation and infection by increasing their cytotoxic, cytokine and inflammatory signatures. Thus high GNLY expression defines a unique dNK type with active roles in innate immune defense in humans and Rhesus macaques. Defining the regulatory networks of GNLY expression by dNK and their mechanism of infection control will open up therapeutic opportunities to enhance immunity and reduce infection-related pregnancy complications

2025-04-01 | GSE282837 | GEO

Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense.

Project description: Not available

| S-EPMC12329683 | biostudies-literature

Transcriptional profiling of human decidual CD45RA+ and CD45RA- primed CD8 T cells by bulk RNA-seq

Project description:Deciphering the immune privilege of maternal-fetal interface is critical to understand how reproductive success and host defense are simultaneously maintained. Here, we identify a conserved subset of effector-like memory CD8⁺ T cells that are preferentially infiltrate in the decidua of both humans and mice, via the CX3CL1–CX3CR1 axis. Murine decidual CX3CR1⁺ memory CD8⁺ T cells and human decidual CD45RA⁺ CD8⁺ T cells share transcriptional and functional programs, characterized by reduced cytokine output but enhanced cytotoxic granule production. We show that decidual stromal cells upregulate CX3CL1 during decidualization, which recruits CX3CR1⁺ cells via receptor engagement and internalization. Functionally, these cells mediate enhanced local protection against Listeria monocytogenes infection at the fetal-maternal interface in a CX3CL1-dependent manner, without contributing to fetal damage. These findings define a conserved mechanism by which decidual tissues selectively enrich effector-like memory CD8⁺ T cells, enabling localized pathogen surveillance while maintaining maternal–fetal tolerance.

2026-09-04 | GSE307408 | GEO

Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection

Project description:A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that mediate the decidual immune response associated with the T. gondii infection, a large-scale study employing TMT proteomics was conducted to characterize the differential decidual immune proteomes from infected and uninfected human decidual immune cells samples. The decidual immune cells from 105 human voluntary abortion tissues were purified, and of the 5510 unique proteins identified, 181 proteins were found to be differentially abundant (>1.2-fold cutoff, P＜0.05) in the T. gondii-infected decidual immune cells. 11 proteins of 181 differentially expressed proteins associated with trophoblast invasion, placental development, intrauterine fetal growth, and immune tolerance were verified using a quantitative real-time polymerase chain reaction and western blotting. This systematic research identified a broad range of immune factors in human decidual immune cells, shedding a new insight into the decidual immune molecular mechanism for abnormal pregnancy outcomes associated with T. gondii infection.

2018-07-27 | PXD008448 | Pride

FOHM data share

Project description:FOHM data share

| PRJEB28249 | ENA

Framingham SHARe Social Network

Project description:Framingham SHARe Social Network

| PRJNA75945 | ENA

Human decidual macrophage clustering

Project description:First trimester decidual macrophages were clustered into three subpopulations by CCR2 and CD11c

2018-10-11 | GSE89323 | GEO

Epigenetic aging of the prefrontal cortex and cerebellum in humans, chimpanzees, and rhesus macaques

Project description:Genome-wide prefrontal cortex and cerebellum DNA methylation profiles of younger and older adult humans, captive chimpanzees, and captive rhesus macaques

2021-04-07 | GSE154403 | GEO

Decidual-tissue resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

Project description:Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to infant neurodevelopmental disabilities. An improved knowledge of correlates of protection against cCMV is needed to guide prevention strategies. Here, we employed a unique ex vivo model of human CMV (HCMV) infection in decidual tissues of women with and without preconception immunity, recapitulating nonprimary versus primary infection at the authentic maternofetal transmission site. We showed that decidual tissues of women with preconception immunity exhibited intrinsic resistance to HCMV, mounting a rapid activation of tissue resident memory CD8+ and CD4+ T cells upon nonprimary infection. We further revealed the role of HCMV-specific decidual-tissue resident CD8+ T cells in local protection against nonprimary HCMV infection. The findings could inform the development of vaccine against cCMV, and provide insights for further studies of the integrity of immune defense against cCMV and other pathogens in the human maternal-fetal interface.

2024-08-01 | GSE240976 | GEO

Adult hippocampal neurogenesis in aged macaques and humans

Project description:Adult hippocampal neurogenesis in aged macaques and humans

| PRJNA687392 | ENA