Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Intestinal microenvironment intervention by live and heat-inactivated Bifidobacterium animalis J12 before pregnancy ameliorates neurodevelopmental abnormalities in prenatally stressed rat offspring by activating focal adhesion pathways in hippocampus

PROVIDER: PRJNA1191365 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31527300.fastq.gz	Fastqsanger.gz
	SRR31527301.fastq.gz	Fastqsanger.gz
	SRR31527302.fastq.gz	Fastqsanger.gz
	SRR31527303.fastq.gz	Fastqsanger.gz
	SRR31527304.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 102

Similar Datasets

Project description:Intestinal microenvironment intervention by live and heat-inactivated Bifidobacterium animalis J12 before pregnancy ameliorates neurodevelopmental abnormalities in prenatally stressed rat offspring by activating focal adhesion pathways in hippocampus

| PRJNA1332351 | ENA

| PRJNA1227898 | ENA

Intestinal microenvironment intervention by live and heat-inactivated Bifidobacterium animalis J12 before pregnancy ameliorates neurodevelopmental abnormalities in prenatally stressed rat offspring by activating focal adhesion pathways in hippocampus

Project description:Prenatal stress has the potential to induce emotional and cognitive impairments in the progeny, impacting their neurological growth significantly. It is still unknown whether intestinal microenvironment intervention by probiotics before pregnancy can alleviate PS and improve the health of the offspring.This findings provided that B. animalis J12 live and heat-inactivated cells significantly reduced the concentration of corticosterone in serum of PS rats, ameliorated the neurological damage and increased the abundance of neurodevelopmentally beneficial species in the intestine of offspring, such as Lactobacillus, Romboutsia, unclassified__f__Oscillospiraceae, unclassified__f__Lachnospiraceae, and others. B. animalis J12 live and heat-inactivated cells increased the intestinal levels of Sterigmatocystin and Phosphocreatine. By modulating the structure of intestinal flora, B. animalis J12 live cells activated the focal adhesion pathway and inhibited complement activation, heat-inactivated cells activated the focal adhesion pathway and increased the expression of glutamine transporter proteins to alleviate neurological damage and neuroinflammation, and to improve learning and memory disorders as well as affective disorders.

2024-11-30 | PXD058455 |

Project description:Intestinal microenvironment intervention by live and heat-inactivated Bifidobacterium animalis J12 before pregnancy ameliorates neurodevelopmental abnormalities

| PRJNA1227905 | ENA

Mus musculus

Project description:Focal Adhesion Kinase Dependent Expression

| PRJNA187977 | ENA

Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment

Project description:The goal of this study was to compare transcriptional profiles of the amygdala from control and (PS) prenatally stressed male and female offspring to elucidate sex-specific molecular mechanisms underlying behavioral and neuroendocrine abnormalities observed after in-utero psychosocial stress exposure. Amygdalar mRNA profiles of 28 day old control and PS male and female mice were generated by preparing sequencing libraries using the NEBNext Ultr II Directional RNA Library Prep Kit for Illumina. After indexing, enrichment through 8 cycles of PCR, and passing initial quality control metrics, individually indexed and compatible libraries were proportionally pooled and sequenced using Nextseq 550 sequencer. The sequencing setting of single read 1 × 85 bp to generate ∼50 M reads per sample was used. Differentially expressed genes (DEGs) were analyzed using RUVseq and EdgeR. Results were validated via qPCR We find psychosocial PS results in the emergence of anxiety-like behaviors, an altered behavioral coping strategy to stress, and anhedonia in male and female offspring. Neuroendocrine abnormalities, evidenced by acute stress-induced HPA axis hyperactivity, are only observed in PS female offspring. Our RNA-seq analysis reveals these phenotypic changes in PS offspring to be associated with sex-specific disturbances in genes associated with synaptic transmission, including genes associated with glutamatergic and GABAergic signaling in PS males, and upregulation of DBH, known to regulate NE synthesis, in PS females. Our study represents one of the first detailed analysis of amygdalar transcriptomes generated by RNA-seq comparing control vs prenatally stressed offspring, identifying sex-specific changes in response to in-utero psychosocial stress exposure.

2022-02-08 | GSE189330 | GEO

Male Rat DNA methylation in the Prefrontal Cortex at postnatal day 62 following prenatal restraint stress

Project description:DNA methylation profiling of Prefrontal Cortex of male rats at postnatal day 62 whose mothers were exposed to restraint stress from gestation day 14 until delivery The groups consist of 1. Control rats (Ctrl) 2. Prenatally stressed rats (PNS)

2016-07-06 | E-GEOD-84021 | biostudies-arrayexpress

Project description:Gene expression in the Amygdala of Prenatally Stressed Brahman Cattle

| PRJNA850510 | ENA

Inactivated M. tuberculosis and M.tuberculosis Infection remodels the macrophage response

Project description:Background: Tuberculosis (TB) remains a major public health problem, especially in developing countries, with 1.5 million deaths annually worldwide. Macrophages (Mφs) are central to TB pathogenesis. Mφs play a key role in the outcome of the infection. More importantly, Mφs are the primary cell target of MTB, which has developed different strategies to multiply inside the Mφ phagosome. Here we aim to compare the transcriptome of Mycobacterium tuberculosis (MTB)-infected Mφs with that of cells stimulated with heat-killed MTB. Results: Here, we used live and heat-inactivated MTB to examine the impact of infection on the human macrophage response. Gene expression profiling has revealed about 3,259 genes differentially expressed in macrophages incubated with heat-inactivated MTB and 4,179 genes differentially expressed with live MTB. We found that the response to live and heat-inactivated MTB was strongly correlated (r>0.78). Conclusions: Our results show that macrophages respond in a similar manner to live and heat-inactivated MTB. We also identified some genes differentially expressed only in one condition.

2020-04-29 | GSE143627 | GEO

Gene expression data from lung of mice infected with H5N1 or H1N1 virus

Project description:To find the different host response during H5N1 and H1N1 infection, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed in mouse lungs infected by H5N1 and H1N1 virus. BALB/c mice were infected with live H5N1 virus , live H1N1 virus, or inactivated H5N1 virus or allantoic fluid (AF) for 24 h. Mice were intra-tracheally inoculated with 106 TCID50 of live H5N1 virus or an identical volume of inactivated H5N1 virus , 106 TCID50 of live H1N1 virus, or allantoic fluid (AF). After 24 hours, lungs were taken for RNA extraction and hybridization on Agilent microarrays.H5N1 and H1N1 virus induced gene expression in mouse was measured. This experiment was performed with 3 mice in each group.

2016-01-12 | E-GEOD-76719 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data