Project description:Cerebral ischemia-reperfusion (I/R) injury triggers acute neuroinflammation, which exacerbates neuronal damage and functional deficits. Laminaria japonica polysaccharide (LJP) has been reported to exert anti-inflammatory and neuroprotective effects, but its molecular mechanisms in I/R injury remain unclear. In this study, we performed transcriptome sequencing on ischemic brain tissues from Sham, Vehicle, and LJP-treated mice to elucidate the molecular mechanisms underlying LJP’s anti-inflammatory actions. Our results show that LJP treatment significantly modulated the expression of key genes involved in inflammatory responses, particularly through the regulation of Csf3-mediated pathways. These findings provide novel insights into the therapeutic potential of LJP for ischemic stroke and identify potential targets for future interventions.
2026-04-22 | GSE328360 | GEO
Project description:Transcriptome data of Laminaria japonica under amantadine stress
| PRJNA1133943 | ENA
Project description:The effect of Laminaria japonica on gut health in piglets
Project description:The proteome of the gametophytes of Diplazium maximum, a temperate Himalayan Polypoidale fern was studied in response to micro-environmental changes. The study was expected to reveal the key proteins associated with a gametophyte’s response to sucrose mediated changes in osmotic potential. A major aim of the study was to identify proteins that would express differentially under micro-environmental stress and also to gain an understanding of the adaptive responses/competence of D. maximum gametophytes. The genes/proteins identified in the study have potential utility in various crop improvement programs.
