Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA119259 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:B cell chronic lymphocytic leukemia - A model with immune response
Seema Nanda 1, , Lisette dePillis 2, and Ami Radunskaya 3,
1.
Tata Institute of Fundamental Research, Centre for Applicable Mathematics, Bangalore 560065, India
2.
Department of Mathematics, Harvey Mudd College, Claremont, CA 91711
3.
Department of Mathematics, Pomona College, Claremont, CA, 91711, United States
Abstract
B cell chronic lymphocytic leukemia (B-CLL) is known to have substantial clinical heterogeneity. There is no cure, but treatments allow for disease management. However, the wide range of clinical courses experienced by B-CLL patients makes prognosis and hence treatment a significant challenge. In an attempt to study disease progression across different patients via a unified yet flexible approach, we present a mathematical model of B-CLL with immune response, that can capture both rapid and slow disease progression. This model includes four different cell populations in the peripheral blood of humans: B-CLL cells, NK cells, cytotoxic T cells and helper T cells. We analyze existing data in the medical literature, determine ranges of values for parameters of the model, and compare our model outcomes to clinical patient data. The goal of this work is to provide a tool that may shed light on factors affecting the course of disease progression in patients. This modeling tool can serve as a foundation upon which future treatments can be based.
Keywords: NK cell, chronic lymphocytic leukemia, mathematical model, T cell., B-CLL.
2020-01-09 | MODEL2001090002 | BioModels
Project description:Transcription profiling of human B lineage chronic lymphocytic leukemia, normal B, and normal T cells treated with rolipram, a PDE4 inhibitor
2025-01-24 | E-GEOD-13987 | ExpressionAtlas
Project description:Expression data from chronic lymphocytic leukemia (CLL) cells
| PRJNA284372 | ENA
Project description:NHL GWAS: Chronic Lymphocytic Leukemia (CLL) Cases
| PRJNA261462 | ENA
Project description:Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with valproic acid
2025-01-24 | E-GEOD-14973 | ExpressionAtlas
Project description:Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with LMP-420
2025-01-24 | E-GEOD-20211 | ExpressionAtlas
Project description:The UC San Diego Chronic Lymphocytic Leukemia (CLL) Study
| PRJNA253638 | ENA
Project description:Analysis of T-cells isolated from CD3+ T-cells of patients with B-cell chronic lymphocytic leukemia (B-CLL). In contrast to other types of cancers, the non-malignant T-cell compartment of B CLL patients is expanded. Results provide insights into the role of T-cells in B-CLL. Purified T-cells of B-CLL patients and normal donor T-cells were analyzed on microarrays to identify differentially expressed genes. The normal donor T-cell control data sets (n=8) have been previously published in the GDS2908 record.
2009-11-25 | E-GEOD-19147 | biostudies-arrayexpress
Project description:This study investigates genomic imbalance in chronic lymphocytic leukemia (CLL) and aims to identify genomic gains and losses with prognostic significance. Two-condition experiment, Test CLL specimens vs. Reference human genome DNA equimixture of normal male and normal female.
2013-09-07 | E-GEOD-40834 | biostudies-arrayexpress
Project description:Transcription profiling by array of human B cells from patients with chronic lymphocytic leukemia after co-culture with nurse-like cells
2025-01-24 | E-GEOD-13811 | ExpressionAtlas