Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human gut

ABSTRACT: Effects of a Non-Pharmacological Multidomain Intervention in Older Adults

PROVIDER: PRJNA1194361 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31630700_1.fastq.gz	Fastqsanger.gz
	SRR31630700_2.fastq.gz	Fastqsanger.gz
	SRR31630701_1.fastq.gz	Fastqsanger.gz
	SRR31630701_2.fastq.gz	Fastqsanger.gz
	SRR31630702_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 108

Similar Datasets

Effects of a Non-Pharmacological Multidomain Intervention in Older Adults

Project description:Effects of a Non-Pharmacological Multidomain Intervention in Older Adults

| PRJNA1268388 | ENA

Effects of a Non-Pharmacological Multidomain Intervention in Older Adults

Project description:This study aimed to investigate the effects of a multidomain intervention on gene expression profile of older adults with cognitive frailty in Selangor, Malaysia, using mRNA gene sequencing. The intervention included a combination of dietary changes, exercise, and psychosocial support. By analyzing gene expression profile in both groups, this study explores how multidomain interventions may influence mrna in older adults. The findings could provide insights into the role of lifestyle factors on the CF in aging populations.

2025-05-31 | GSE298126 | GEO

Human gut

Project description:Gut Microbiota of Community-dwelling Older Adults from the AGELESS Cohort

| PRJNA1194316 | ENA

Human gut microbiome upon a strawberry-based intervention on healthy elderly adults

Project description:Strawberry intervention effects in the gut microbiome of healthy elderly adults

| PRJEB83578 | ENA

The effects of a novel oral nutritional supplement as compared to standard care on body composition, physical function and skeletal muscle mRNA expression in Dutch older adults with (or at risk of) undernutrition

Project description:In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). Gait speed during 4m and 400m tests improved over time in the intervention group, whereas the standard care showed no improvements (time*treatment effects 400m: p=0.038 and 4m: p=0.048). Gene sets related to mitochondrial functioning were strongly upregulated in the participants receiving the intervention product. We showed that a novel oral nutritional supplement improves gait speed in older adults via improvements in mitochondrial functioning.

2021-04-06 | GSE136395 | GEO

human stool samples

Project description:Impact of a Multidomain Telehealth Intervention on Gut Microbiota, Intestinal Permeability, and Inflammation in Older Adults

| PRJNA1265790 | ENA

Repetitive element transcript accumulation is related to inflammaging in humans

Project description:Inflammation is an established feature of many age-related diseases, and growing evidence implicates transcripts from repetitive elements in inflammatory signaling with aging. We generated transcriptomic (RNA-seq) and whole-genome bisulfite sequencing (WGBS, for methylation) data on frozen/biobanked peripheral blood mononuclear cells from middle-aged and older adults, as well as younger and older adults before and after an exercise intervention, to evaluate correlations among repetitive elements and inflammation, along with methylation of repetitive elements.

2024-04-09 | GSE263013 | GEO

Shatavari Supplementation During Eight Weeks of Resistance Training Increases Training Load, Enhances Skeletal Muscle Contractility and Alters the Skeletal Muscle Proteome in Older Women.

Project description:Shatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function. However, mechanistic insights are limited and the effects of shatavari on muscle function require further characterization. In this randomised, double-blind trial, 17 young (23 ±5yr) and 22 older (63±5yr) women completed an eight-week leg resistance training programme. They consumed either a placebo or shatavari (1000mg/d, equivalent to 26,500 mg/d fresh weight) supplement throughout. Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. Tandem-mass-tagged VL proteomic analyses were performed. Additionally, resistance training (RT) is the gold standard intervention for ameliorating sarcopenia. Outstanding mechanistic questions remain regarding the malleability of the molecular determinants of skeletal muscle function in older age. Discovery proteomics can expand such knowledge. We further aimed to compare the effect of RT on the skeletal muscle proteome and neuromuscular function (NMF) in older and younger women.

2024-10-22 | PXD056507 | Pride

Project description:Depression in older adults

| PRJNA991320 | ENA

Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes muscle atrophy

Project description:The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to prevent or reverse this debilitating condition. Long non-coding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a wide variety of tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging-induced lncRNA with high abundance in human skeletal muscle. In a cohort of healthy young and older adults, skeletal muscle FRAIL1 was most strongly expressed in older females and negatively associated with measures of muscle strength and mass. Forced expression of FRAIL1 in mouse tibialis anterior muscle elicits a dose-dependent reduction in skeletal muscle fiber size that is independent of changes in muscle fiber type. Furthermore, this reduction in muscle size is dependent on an intact region of FRAIL1 that is highly conserved across non-human primates. Unbiased transcriptional and proteomic profiling of the effects of FRAIL1 expression in mouse skeletal muscle revealed widespread changes in mRNA and protein abundance that recapitulate age-related changes in pathways and processes that are known to be altered in aging skeletal muscle. Taken together, these findings shed light on the intricate molecular mechanisms underlying skeletal muscle aging and implicate FRAIL1 in the reduction of muscle mass during this process.

2024-02-24 | GSE249356 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data