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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center

ABSTRACT: Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center

PROVIDER: PRJNA1194957 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR23446705_1.fastq.gz	Fastqsanger.gz
	SRR23446705_2.fastq.gz	Fastqsanger.gz
	SRR23446707_1.fastq.gz	Fastqsanger.gz
	SRR23446707_2.fastq.gz	Fastqsanger.gz

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [CHART-seq]

Project description:Known to regulate chromosome looping on a genome-wide scale, the noncoding Jpx RNA was originally shown to control X-chromosome counting and induce Xist expression during X-chromosome inactivation (XCI). Not fully understood is how Jpx upregulates Xist in coordination with Tsix downregulation in cis. Here, by integrating epigenomic data and polymer modeling in a mouse embryonic stem cell model, we demonstrate that Jpx controls architectural and transcriptional dynamics within anti- and pro-XCI zones of the X-inactivation center. Distinct topological changes occur on the future active (Xa) and inactive (Xi) chromosomes. Jpx binds the enhancer of Tsix on the future Xi and alters loop formation to favor Xist induction, coordinately releasing CTCF from Tsix and Xist in cis on the future Xi. Thus, by controlling a dynamic rewiring of functional loops, Jpx flips a transcriptional switch to control mutually exclusive Tsix and Xist expression in cis.

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [RNA-Seq]

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [Capture Hi-C]

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [RNA-Seq]

Project description:Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [RNA-Seq]

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [CHART-seq]

Project description:Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [CHART-seq]

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [Capture Hi-C]

Project description:Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center [Capture Hi-C]

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Species-specific regulation of XIST by the JPX/FTX orthologs

Project description:X chromosome inactivation (XCI) is a developmental regulatory process that initiates with remarkable diversity in various mammalian species. Here we addressed the contribution of XCI regulators, most of which are lncRNA genes (LRGs) characterized in the mouse, to this mechanistic diversity. By combining analysis of single-cell RNA-seq data from early human embryogenesis with various functional assays in pluripotent stem- and differentiated cells, we demonstrate that the function of Ftx is not conserved, while JPX stands a major regulator of XIST expression in human and in mouse. However, the underlying mechanisms differ radically between species and require Jpx RNA in the mouse and the act of transcription of the JPX locus in the human. Moreover, biogenesis of XIST is affected at different regulatory steps between these species. This study illustrates how diversification of LRG modus operanti during evolution provide opportunities for innovations within constrained gene regulatory networks.

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Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center

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