Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1195847 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR31646814_1.fastq.gz | Fastqsanger.gz | |||
| SRR31646814_2.fastq.gz | Fastqsanger.gz | |||
| SRR31646815_1.fastq.gz | Fastqsanger.gz | |||
| SRR31646815_2.fastq.gz | Fastqsanger.gz | |||
| SRR31646816_1.fastq.gz | Fastqsanger.gz |
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Project description:Sulfoquinovose (SQ) and sulfoquinovosyl glycerol (SQGro), derived from abundant membrane sulfolipids termed sulfoquinovosyl diacylglycerols (SQDG) produced by photosynthetic organisms, serve as sources of carbon and sulfur for bacteria. The conversion processes of these sulfoquinovosyl compounds (SQ, SQGro, and SQDG) within marine ecosystems, and their quantitative contributions to the marine organic matter pool, are poorly understood. We have identified Alteromonas macleodii, a cosmopolitan marine bacterium, as a novel organism capable of metabolizing SQ and SQGro. A. macleodii possesses a sulfoquinovosidase that converts SQGro to SQ, and is a member of a distinct clade within glycoside hydrolase family 31 distinct from other sulfoqinovosidases. The ubiquitous presence of sulfoquinovosidases and their transcripts throughout marine environments suggests active metabolism of sulfoquinovose glycosides, particularly in the sunlit surface ocean. Complementing these observations, we demonstrate that marine algae and cyanobacteria produce significant quantities of SQGro, and field samples from coastal and open ocean environments enabled estimation of the annual turnover of SQGro in the teragram range. Together with SQDG and SQ, these sulfoquinovosyl compounds constitute a substantial portion of the marine organic sulfur, estimated at around 1.5 petagrams of carbon turnover per annum. These findings reveal a vast, previously unappreciated pool of organosulfonates within the microbial food web that contributes significantly to the marine carbon and sulfur cycles.
2025-08-25 | PXD058686 | Pride
Project description:Sulfoquinovose (SQ) and sulfoquinovosyl glycerol (SQGro), derived from abundant membrane sulfolipids termed sulfoquinovosyl diacylglycerols (SQDG) produced by photosynthetic organisms, serve as sources of carbon and sulfur for bacteria. The conversion processes of these sulfoquinovosyl compounds (SQ, SQGro, and SQDG) within marine ecosystems, and their quantitative contributions to the marine organic matter pool, are poorly understood. We have identified Alteromonas macleodii, a cosmopolitan marine bacterium, as a novel organism capable of metabolizing SQ and SQGro. A. macleodii possesses a sulfoquinovosidase that converts SQGro to SQ, and is a member of a distinct clade within glycoside hydrolase family 31 distinct from other sulfoqinovosidases. The ubiquitous presence of sulfoquinovosidases and their transcripts throughout marine environments suggests active metabolism of sulfoquinovose glycosides, particularly in the sunlit surface ocean. Complementing these observations, we demonstrate that marine algae and cyanobacteria produce significant quantities of SQGro, and field samples from coastal and open ocean environments enabled estimation of the annual turnover of SQGro in the teragram range. Together with SQDG and SQ, these sulfoquinovosyl compounds constitute a substantial portion of the marine organic sulfur, estimated at around 1.5 petagrams of carbon turnover per annum. These findings reveal a vast, previously unappreciated pool of organosulfonates within the microbial food web that contributes significantly to the marine carbon and sulfur cycles.
2025-08-25 | PXD058710 | Pride
Project description:Crustose coralline algae associated bacteria Raw sequence reads
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Project description:Enrichment culturing of bromoform metabolizing bacteria
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Project description:Abstract. Background. Treatment for lung adenocarcinoma (AD) and squamous cell carcinoma (SQ) is similar and shows comparable poor efficacy. We investigated whether microRNA (miR) expression profiles can differentiate histological subtypes, predict survival, and suggest histology-specific targets for treatment. Methods. We analyzed miR expression in 165 AD and 125 SQ tissue samples from the Environmental And Genetics in Lung cancer Etiology (EAGLE) study using a custom oligo array with 440 human mature antisense miRs. We compared miR expression profiles using t-tests and F-tests and accounted for multiple testing using global permutation tests. We categorized miR-targeted genes using Gene Ontology. We assessed the association of miR expression with clinical outcome using log-rank tests, Cox proportional hazards and survival risk prediction models, accounting for demographic and tumor characteristics. Findings. MiR expression profiles strongly differed between AD and SQ (global p<0.0001), particularly in the early stages. All members of the let-7 family and other oncosuppressor miRs were down-regulated in SQ, while oncomiRs like miR-21 were up-regulated in AD. The miRs with the strongest expression differences are located on chromosome loci most often altered in lung cancer (e.g., 3p21-22). Major findings were confirmed by QRT-PCR in EAGLE samples and in an independent cohort. In SQ, low expression of miRs down-regulated in the histology comparison was associated with 1.2 to 3.6-fold increased mortality risk. A 5-miR signature significantly predicted survival for SQ. Interpretation. We identified a miR expression profile that strongly differentiated AD from SQ and had prognostic implications. These findings may lead to histology-based therapeutic approaches.
2010-03-11 | GSE15201 | GEO
Project description:Transcriptomic analysis comprehensively revealed the metabolic improvement effects of di-SQ on the liver and white adipose tissue in ob/ob mice. Di-SQ demonstrated effects in improving inflammation and lipid metabolism in both the liver and white adipose tissue of ob/ob mice and restored the expression of genes and GO terms associated with mitochondrial respiration and glucose metabolism. The metabolic disorder observed in untreated ob/ob mice was reversed by a 42-day-di-SQ treatment, the di-SQ treated ob/ob mice showed a gene expression pattern in key metabolic pathways and processes that more closely resembles that of wild-type mice.
2024-12-10 | GSE281432 | GEO
Project description:Expression data from SQ, TRI-SQ and Tetra-SQ-treated HFDPCs
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