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Spatially resolved chimeric analysis reveals extracellular CKB-mediated ATP uptake at the glioma-astrocyte invasive front

ABSTRACT: Spatially resolved chimeric analysis reveals extracellular CKB-mediated ATP uptake at the glioma-astrocyte invasive front

PROVIDER: PRJNA1196402 | ENA |

REPOSITORIES: ENA

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Spatially resolved chimeric analysis reveals extracellular CKB-mediated ATP uptake at the glioma-astrocyte invasive front

Project description:Glioblastoma (GBM) is a highly invasive primary brain tumor that, although rarely metastasizing outside the brain, frequently infiltrates surrounding brain tissue. This infiltrative growth may exploit the brain’s metabolic support system, which involves various brain-resident cells providing essential nutrients and maintaining energy balance. In this study, we investigated the metabolic dependencies of infiltrative GBM cells by combining spatially resolved transcriptomic profiling with advanced computational methods in xenografted GBM models. Our findings reveal that GBM cells upregulate creatine kinase brain type (CKB) at the leading edge to adapt to local energy deprivation. CKB facilitates the conversion of creatine to phosphocreatine, utilizing ATP supplied by astrocytes to support tumor cell survival and invasion. Targeting CKB with cyclocreatine significantly reduced tumor size and restricted infiltrative growth in vivo, indicating that GBM cells utilize CKB to harness extracellular ATP via the creatine pathway. These findings suggest that targeting CKB in GBM may offer a novel therapeutic strategy to combat infiltrative growth in this aggressive cancer.

2025-06-30 | GSE283959 | GEO

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Celtic Sea Front

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Project description:To spatially correlate the pattern of glucose uptake to glucose transporter distributions in cultured lenses and map glucose metabolism in different lens regions.

2022-05-26 | PXD033022 | Pride

Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma

Project description:Invasive tumor front (ITF, the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (uADC) and leiomyosarcomas (uLMS).

2021-04-15 | GSE172043 | GEO

Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma

Project description:Invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. In this study we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression and methylation profiles of classified aggressive primary uterine adenocarcinomas and leiomyosarcomas.

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Microbial community dynamics across an oceanic front

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Expression profiling of stage IIA/MSS colon cancers from whole tumor and invasion front sampling

Project description:The goal was to identify gene expression signatures predictive of early relapse among stage IIA/MSS colon cancer patients. A secondary question addressed was whether the invasion front profiles could generate a competitive signature. 39 whole tumor and 35 matched invasion front profiles were generated (4 samples failed) and grouped into \\"early relapse\\" (relapse within 5 years) and \\"no relapse\\" (no relapse for at least 6 years) categories.

2024-03-25 | E-MTAB-13695 | biostudies-arrayexpress

GRHL3 activates FSCN1 to relax cell adhesions between migrating keratinocytes in the wound front

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miRNA profiles in invasive front of pT1 colorectal cancer

Project description:The goal of the study was to identify miRNAs differentially expressed in the invasive front of early and more advanced colorectal cancers, and to determine wheter miRNA profiles could differentiate between colorectal cancers with and without early metasttic progression. miRNA array data was used for analyses of associations beteen metastatic status and for associations to histopathological risk factors for metastatic progression.

2018-08-01 | GSE110402 | GEO

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