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Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics

ABSTRACT: Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics

PROVIDER: PRJNA1199332 | ENA |

REPOSITORIES: ENA

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Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics [Spatial Transcriptomics]

Project description:Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics [Spatial Transcriptomics]

| PRJNA1206228 | ENA

Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics

Project description:Huntington’s disease (HD) is a progressive neurodegenerative disease marked by widespread cellular disruption. To understand disease mechanisms by investigating transcriptional differences, we and others have utilized bulk and single cell transcriptomics which provide cell type information but limited spatial information. We therefore utilized 10x Genomics Visium spatial transcriptomics integrated with matched single nuclei-RNA-seq in the HD R6/2 mouse brain (postnatal day 0, 4- and 12-week) to examine disease trajectories across regions in a rapidly progressing model. Our data suggests regional, temporal and cell type specific regulatory pathways that establish distinct gene expression changes in brain. Synaptic dysfunction is observed broadly throughout the brain. We observed early dysregulation of the transcription factor Tcf-4 that may drive cortical changes. Mitochondrial deficits are the earliest changes, beginning at P0 in striatum prior to overt symptom onset together with increased expression of striatal identity genes that then become progressively downregulated. Finally, we identified a time-dependent dysregulation of neuropeptide Y signaling and potential interaction with the cAMP/PKA pathway, which may be involved in early imbalance between Drd1 and Drd2 neuron vulnerability.

2025-06-24 | GSE284468 | GEO

Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics [Spatial Transcriptomics]

2025-06-24 | GSE285858 | GEO

Six-week-old R6/2 HD mouse striatum

Project description:Wild-type CBAxC57BL/6 (6 weeks of age) and HD Exon 1 R6/2 CBAxC57BL/6 (6 weeks of age). Control groups for two drug studies. All animals injected with normal saline 30-60 minutes prior to sacrifice. Keywords: parallel sample

2011-10-13 | GSE1980 | GEO

ChIPseq on bulk striatal tissue of 15-20 week-old HD R6/1 mice

Project description:To characterize striatal epigenome of HD R6/1 mice

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Six-week-old R6/2 HD mouse striatum

2011-10-12 | E-GEOD-1980 | biostudies-arrayexpress

Cut&Tag of 15 week-old HD R6/1 mice in neuronal cell populations.

Project description:To characterize the epigenome of HD R6/1 mice in striatal cells using CUT&TAG on neuronal nuclei

2025-01-08 | GSE282238 | GEO

ChIPseq of 15-20 week-old R6/1 HD mice in neuronal and non-neuronal striatal cell populations

Project description:To characterize the epigenome of R6/1 HD mice in specific striatal cellular populations

2025-01-08 | GSE262075 | GEO

Cut&Tag of 20 week-old HD R6/1 mice in neuronal and non-neuronal striatal cell populations.

Project description:To characterize the epigenome of HD R6/1 mice in striatal cells using CUT&TAG on neuronal and non-neuronal nuclei

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Transcription profiling of HD R6/1 transgenic mouse line brain hemispheres, time series

Project description:HD R6/1 transgenic mouse line brain hemispheres dissected. RNA targets were created for transgenics and wildtypes at time points 18, 22 and 27 weeks. Profiles and data analysis performed using the Bioconductor software and linear model contrasts using LIMMA on RMA probeset summarys. Experiment Overall Design: 18 samples extracted, 3 transgenic plus 3 littermate controls analysed at each timepoint.

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