Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [ChIP-seq]

ABSTRACT: TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [ChIP-seq]

PROVIDER: PRJNA1199461 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR31751501_1.fastq.gz	Fastqsanger.gz
	SRR31751501_2.fastq.gz	Fastqsanger.gz
	SRR31751502_1.fastq.gz	Fastqsanger.gz
	SRR31751502_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 91

Similar Datasets

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination

Project description:The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number of interacting proteins, many AR coregulators remain to be characterized in relation to their distinct impact on AR function. Here, we describe TRIM33 as a conserved AR-interactor across multiple prostate cancer cell lines. We observed that TRIM33 and AR share overall chromatin interaction profiles, in which TRIM33 is involved in downstream responsive transcriptomic output. In contrast to prior reports, we show that TRIM33 does not impact AR protein stability, but instead propose a model in which TRIM33 facilitates maximal AR activity by interfering with H2BK120 ubiquitination levels.

2025-06-16 | PXD058914 | Pride

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [ChIP-seq]

2025-06-10 | GSE284519 | GEO

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [RNA-seq]

2025-06-10 | GSE284520 | GEO

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination

Project description:TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination

| PRJNA1199459 | ENA

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [RNA-seq]

Project description:TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [RNA-seq]

| PRJNA1199467 | ENA

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-06-10 | GSE284522 | GEO

The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [DSB]

Project description:Deregulation of RNA polymerase II (RNAPII) by oncoproteins, such as transcription factor Myc, interferes with DNA replication and is a major source of DNA damage and genomic instability. Ubiquitination is a key pathway controlling RNAPII activity via modification of RNAPII subunits or associated regulatory proteins. We uncover a mechanism for genome maintenance by ubiquitin ligase Trim33 and transcription factor E2f4. We show that Trim33 promotes E2f4 protein turnover, restricting interactions of E2f4 with chromatin and with the Recql DNA helicase. Replicative stress blunts Trim33-dependent regulation, which stimulates Recql recruitment to chromatin and facilitates recovery of DNA synthesis. Deletion of Trim33 triggers chronic recruitment of Recql and accelerates DNA replication under stress, accompanied by compromised DDR signaling and DNA repair. Depletion of Trim33 in Myc-overexpressing cells leads to accumulation of replication-associated DNA damage and delays Myc-driven tumorigenesis. We propose that the Trim33-E2f4-Recql axis provides a mechanism to control DNA replication at transcriptionally active chromatin to maintain genome integrity.

2023-07-28 | GSE217521 | GEO

The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [RNA-seq]

2023-07-28 | GSE217523 | GEO

The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [ChIP-seq]

2023-07-28 | GSE217519 | GEO

The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [Cut&Run]

2023-07-28 | GSE217520 | GEO