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Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [RNA-seq]

ABSTRACT: Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [RNA-seq]

PROVIDER: PRJNA1200649 | ENA |

REPOSITORIES: ENA

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Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [CUT&Run]

Project description:Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [CUT&Run]

| PRJNA1200651 | ENA

Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [Hi-C]

Project description:Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [Hi-C]

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Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [TT-seq]

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Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [CUT&Run]

Project description:Human cytomegalovirus extensively alters nuclear organization and the cellular transcriptome, yet our understanding of these events remains relatively limited. Here, chromatin conformation capture reveals that cytomegalovirus dramatically alters chromosome organization at both large-scale and local compartment levels. Nascent transcriptomics further reveals the extent to which transcriptional changes correlate with compartment changes, while also uncovering infection-induced read-in and read-through events that result in the expression of normally repressed neuronal genes in infected fibroblasts. Moreover, we find that viral genomes preferentially localize to the most abundant and euchromatic compartments of the host, further dysregulating transcription of subsets of host genes. Finally, we show that microtubule-derived forces on the nucleus regulate viral interactions with host chromatin as well as local compartment interactions, which in turn influences infection-induced transcriptional reprogramming. Combined, our findings reveal the extent to which HCMV alters chromatin organization and transcriptional activity, along with the contribution of microtubules to these processes.

2025-07-23 | GSE284782 | GEO

Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [RNA-seq]

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Acetylated microtubules refine cytomegalovirus interactions with and remodeling of host chromatin [TT-seq]

2025-07-23 | GSE284780 | GEO

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Polyglutamylation of microtubules drives neuronal remodeling

Project description:Polyglutamylation of microtubules drives neuronal remodeling

| PRJNA1261042 | ENA

Polyglutamylation of microtubules drives neuronal remodeling

Project description:Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. The cytoskeleton is critical for this process, as microtubule loss via enzymatic severing is an early step of pruning across many circuits and species. However, how microtubule-severing enzymes, such as spastin, are activated in specific neuronal compartments remains unknown. Here, we reveal that polyglutamylation, a posttranslational tubulin modification that is enriched in neurons, plays an instructive role in developmental remodeling by tagging microtubules for severing. Motor neuron-specific gene deletion of enzymes that add or remove tubulin polyglutamylation—TTLL glutamylases vs. CCP deglutamylases—accelerates or delays neuromuscular synapse remodeling in a neurotransmission-dependent manner. This mechanism is not specific to peripheral synapses but also operates in central circuits, e.g., the hippocampus. Thus, tubulin polyglutamylation acts as an activity-dependent rheostat of remodeling and shapes neuronal morphology and connectivity.

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Localization profiling of mRNAs associated with microtubules and microtubule bound polysomes in human HeLa cells and unfertilized Xenopus eggs demonstrates conserved localization of mRNAs to mitotic microtubules

Project description:Microtubules were purified from mitotic Xenopus or Hela extracts and associated mRNAs were compared to total extract.

2007-12-31 | E-MEXP-1320 | biostudies-arrayexpress