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Transcriptome analysis of NK92 treated with deferoxamine or PPMX-T003

ABSTRACT: Transcriptome analysis of NK92 treated with deferoxamine or PPMX-T003

PROVIDER: PRJNA1200725 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR31781737_1.fastq.gz	Fastqsanger.gz
	SRR31781737_2.fastq.gz	Fastqsanger.gz
	SRR31781739_1.fastq.gz	Fastqsanger.gz
	SRR31781739_2.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of NK92 treated with deferoxamine or PPMX-T003

Project description:Although several types of iron deprivators are available in laboratory, the differences of them in transcriptome alterations remains unclear. In this study, we performed RNA-seq analysis of NK92 cells treated with deferoxamine (DFO; an iron chelator) and PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody) to investigate the differences in transcriptomic alterations between them.

2025-06-25 | GSE284968 | GEO

Analysis of deferoxamine treated leaves and roots: Arabidopsis transcriptome in response to deferoxamine

Project description:au08-04_dfo - analysis of deferoxamine treated leaves and roots - What are the effects of the siderophore deferoxamine on Arabidopsis leaves and roots? - Plants were allowed to grow for 5-6 weeks. The nutrient solution contains 0.25 mM Ca(NO3)2.4H2O, 1mM KH2PO4, 0.5 mM KNO3, 1mM MgSO4.7H2O, 50 µM H3BO3, 19 µM MnCl2.4H2O, 10 µM ZnCl2, 1 µM CuSO4.5H2O, 0.02 µM Na2MoO4.2H2O and 50 µM FeNa-EDTA. Plants were subjected to an 8 h light/16 h dark cycle, at 19°C, with 70% relative humidity. Leaves of six week old hydroponically grown A. thaliana Col0 plants were infiltrated with 1mM deferoxamine or sterile distilled water. Leaves were harvested 7 and 24 h.p.i. Keywords: time course,treated vs untreated comparison

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Proteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003

Project description:This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody) for 24 hours and lysed with RIPA buffer supplied with a proteasome inhibitor cocktail and a phosphatase inhibitor.

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Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

Project description:Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

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Transcriptome analysis of NK92 teated with PPMX-T003 for connectivity scoring analysis

Project description:PPMX-T003, an humanized anti-transferrin receptor 1 inhibitory antibody, has anti-neoplastic potential against mature NK cell neoplasms. However, its molecular mechanism is not elucidated. To investigate, we performed RNAseq of NK92 cells treated with PPMX-T003 to obtain defferentially expressed gene signature and compared it to those of well-known anti-neoplastic agents for prediction of similarity in transcriptomic change.

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Transcriptome analysis of NK92 teated with PPMX-T003 for connectivity scoring analysis

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mRNA expression profiles in YT and NK92 cells

Project description:YT and NK92 cells are EBV-infected lymphoma cells of NK- cell origin. YT cells have weaker expression of T-bet and IFNg than NK92 cells. However, this data set shows that both cell lines have similar mRNA levels, implying post-transcriptional regulations.

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miRNA expression profiles in YT and NK92 cells

Project description:The miRNA expression profiles of of EBV-infected YT and NK92 cells are compared. YT cells have weaker expression of T-bet and IFNg than NK92 cells. It was found that the EBV-encoded miR-BART20-5p inhibits the expression of T-bet and IFNg in YT cells. Approximately 100 ng total RNAs from YT and NK92 cells were used as the input. The GeneChip miRNA 2.0 array from Affymetrix, including probes for 44 EBV-encoded miRNAs and 1105 human miRNAs, was used. The experiments were performed in the microarray core laboratory of National Health Research Institute, Taiwan.

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miRNA expression profiles in YT and NK92 cells

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