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Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells [ATAC-seq]

ABSTRACT: Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells [ATAC-seq]

PROVIDER: PRJNA1201758 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31802868_1.fastq.gz	Fastqsanger.gz
	SRR31802868_2.fastq.gz	Fastqsanger.gz
	SRR31802869_1.fastq.gz	Fastqsanger.gz
	SRR31802869_2.fastq.gz	Fastqsanger.gz
	SRR31802870_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells [RNA-seq]

Project description:In chronic viral infections, sustained CD8+ T cell response relies on TCF1+ precursor exhausted T cells (TPEX) exhibiting stem-like properties. TPEX self-renew and respond to PD-1 blockade, underscoring their paramount importance. However, strategies for effectively augmenting TPEX remain limited. Here, we demonstrate that ZC3H12A deficiency initiates a stemness program in TPEX but also increases cell death, whereas BCOR deficiency predominantly promotes TPEX proliferation. Consequently, co-targeting of both BCOR and ZC3H12A imparts exceptional stemness and functionality to TPEX, thereby enhancing viral control. Mechanistically, BCOR and ZC3H12A collaboratively suppress a core stemness program in TPEX characterized by heightened expression of approximately 216 factors. While TCF1 plays a role, this core stemness program relies on novel factors, including PDZK1IP1, IFIT3, PIM2, LTB, and POU2F2. Crucially, overexpressing POU2F2 robustly boosts TPEX and enhances antiviral immunity. Thus, a core stemness program exists in exhausted T cells, jointly repressed by BCOR and ZC3H12A, robustly controlling TPEX differentiation and providing new targets for addressing T cell exhaustion.

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Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells [ATAC-seq]

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Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells at single cell level [scATAC-seq]

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Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells at single cell level [scRNA-seq]

2025-04-23 | GSE285183 | GEO

Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells [RNA-seq]

Project description:Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells [RNA-seq]

| PRJNA1201754 | ENA

Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells at single cell level [scATAC-seq]

Project description:Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells at single cell level [scATAC-seq]

| PRJNA1201762 | ENA

Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells at single cell level [scRNA-seq]

Project description:Effect of depletion of Bcor, Zc3h12a or both on gene expression of P14 CD8 T cells at single cell level [scRNA-seq]

| PRJNA1201761 | ENA

Effect of overexpression of Empty or POU2F2 on gene expression in P14 CD8 T cells at single cell level [scRNA-seq II]

2025-04-23 | GSE285186 | GEO

Transcription profiling of mouse LPS-stimulated macrophages from wild-type and Zc3h12a-/- knockouts

Project description:Lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand, induces the expression of various genes including proinflammatory cytokines, and the expression is modified by the presence of Zc3h12a. We used microarrays to examine influence of Zc3h12a deficiency in LPS-inducible gene expression. Experiment Overall Design: Peritoneal macrophages from wild-type and Zc3h12a-/- mice were stimulated with LPS for 0, 1, 2 and 4 hours, followed by RNA extraction. Then hybridization on affymetrix microarrays was performed.

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Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation

Project description:To identify vPRC1.1 protein interactions in the context of a mutant BCOR-ITD subunit, we performed cross-linking followed by two-step affinity purification of BioTAP-tagged wildtype BCOR (BCOR-WT) or BCOR-ITD mutant protein in mES cells

2025-06-28 | PXD064792 | Pride

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