Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Modeling heart failure by induced pluripotent stem cell-derived organoids.

ABSTRACT: Modeling heart failure by induced pluripotent stem cell-derived organoids.

PROVIDER: PRJNA1201861 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31805826.fastq.gz	Fastqsanger.gz
	SRR31805827.fastq.gz	Fastqsanger.gz
	SRR31805828.fastq.gz	Fastqsanger.gz
	SRR31805829.fastq.gz	Fastqsanger.gz
	SRR31805830.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Modeling heart failure by induced pluripotent stem cell-derived organoids.

Project description:Cardiac organoids replicate tissue complexity better than 2D models, making them ideal for studying diseases like heart failure (HF). This study developed scaffold-free cardiac organoids from induced pluripotent stem cells (iPSCs) to model HF in vitro. Gene expression analysis confirmed a cardiac phenotype, and endothelin-1 (ET-1) treatment induced HF-like features. Key findings include upregulation of HF markers (ANP, BNP, ACTA1), altered miRNA profiles, reduced contractility, and protein aggregation. Nutraceutical co-treatment mitigated these effects, highlighting the model's utility in understanding HF mechanisms and testing therapies.

2025-04-15 | GSE285213 | GEO

Human iPSC-derived heart organoids modeling the etiology of pregestational diabetes induced congenital heart defects

Project description:Human iPSC-derived organoids modeling the etiology of pregestational diabetes induced congenital heart defects

2023-08-07 | GSE201343 | GEO

INO80 and heart failure.

Project description:INO80 and heart failure.

| PRJNA1002579 | ENA

Human iPSC-derived heart organoids modeling the etiology of pregestational diabetes induced congenital heart defects

Project description:Human iPSC-derived heart organoids modeling the etiology of pregestational diabetes induced congenital heart defects

| PRJNA830899 | ENA

Heart Failure Network: EntrestoTM In Advanced Heart Failure (HFN-LIFE-BioLINCC)

Project description:Heart Failure Network: EntrestoTM In Advanced Heart Failure (HFN-LIFE-BioLINCC)

| PRJNA1290830 | ENA

Heart Failure Network: EntrestoTM In Advanced Heart Failure (HFN-LIFE-BioLINCC)

Project description:Heart Failure Network: EntrestoTM In Advanced Heart Failure (HFN-LIFE-BioLINCC)

| PRJNA1290831 | ENA

GENERATION OF HEART ORGANOIDS MODELING EARLY HUMAN CARDIAC DEVELOPMENT UNDER DEFINED CONDITIONS

Project description:GENERATION OF HEART ORGANOIDS MODELING EARLY HUMAN CARDIAC DEVELOPMENT UNDER DEFINED CONDITIONS

| PRJNA641686 | ENA

Single-cell transcriptional analysis of developmental maturation strategies for human pluripotent stem cell-derived heart organoids

Project description:Human pluripotent stem cells possess the ability to recapitulate key events of mammalian organogenesis in vitro, including heart development. Previously-described human heart organoid protocols elicit early embryonic-like cardiac phenotypes and morphologies. We hypothesized that human heart organoids can be made significantly more complex and physiologically relevant through the implementation of in utero gestational biochemical phenomena. Here, we designed and applied multiple developmental maturation strategies on our human heart organoids for a period of 10 days. Our data reveals the emergence of atrial and ventricular cardiomyocyte populations, valvular cells, epicardial cells, proepicardial-derived cells, endothelial cells, stromal cells, conductance cells, and cardiac progenitors, all of them cell types present in the primitive heart tube.

2023-11-21 | GSE218582 | GEO

Metabolic stress and therapeutic response in heart failure associated with congenital heart disease

Project description:Heart failure in congenital heart disease (CHD) has no effective treatment besides heart transplantation. While hemodynamic etiology is suggested, here we show hypoplastic left heart syndrome (HLHS), a severe CHD is a mitochondrial disease from analysis of HLHS mice and patient derived induced pluripotent stem cell cardiomyocytes (iPSC-CM). The iPSC-CM from patients suffering heart failure or death, but not those with long-term survival, showed reduced cell proliferation with increased apoptosis, mitochondrial hyperfusion with respiration defect and redox stress. Single cell sequencing showed protein synthesis overload with unfolded protein response. Drugs targeting the mitochondria restored metabolic function and rescued cell proliferation and apoptosis, suggesting new stragegies for heart failure therapy in CHD.

2022-04-07 | GSE146341 | GEO

Heart Failure with Preserved Ejection Fraction - Mouse Heart and Lung Tissue & Comorbidities

Project description:FASILOX analysis of heart and lung tissue form mice with heart failure with preserved ejection fraction and several comorbidities.

2024-10-02 | PXD056447 | JPOST Repository

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data