Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mutational profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

ABSTRACT: Mutational profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

PROVIDER: PRJNA1203246 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Mutational profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

Project description:To investigate the biological differences between HIV-, HIV+/ART-experienced and HIV+/ART-naive diffuse large B-cell lymphoma, we performed whole exome sequencing of 30 pre-treatment formalin-fixed paraffin-embedded (FFPE) whole lymph node biopsies of diffuse large B-cell lymphoma.

2025-06-23 | GSE285377 | GEO

Gene expression profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

Project description:Gene expression profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

| PRJNA1092658 | ENA

Gene expression profiling of HIV-associated diffuse large B-cell lymphomas from Malawi

Project description:To investigate the biological differences between HIV-, HIV+/ART-experienced and HIV+/ART-naive diffuse large B-cell lymphoma, we performed RNA sequencing of 70 pre-treatment formalin-fixed paraffin-embedded (FFPE) whole lymph node biopsies of diffuse large B-cell lymphoma.

2024-06-01 | GSE262621 | GEO

RC-DLBCL (Diffuse Large-B Cell Lymphomas)

Project description:RC-DLBCL (Diffuse Large-B Cell Lymphomas)

| PRJNA1311170 | ENA

Genomic Variation in Diffuse Large B Cell Lymphomas

Project description:Genomic Variation in Diffuse Large B Cell Lymphomas

| PRJNA400524 | ENA

Diffuse large B cell lymphomas

Project description:Intrinsic resistance of lymphoma cells to apoptosis is a probable mechanism causing chemotherapy resistance and eventual fatal outcome in patients with diffuse large B cell lymphomas (DLBCL). We investigated whether microarray expression profiling of apoptosis related genes predicts clinical outcome in 46 patients with primary nodal DLBCL. Unsupervised cluster analysis using genes involved in apoptosis (N=246) resulted in 3 separate DLBCL groups partly overlapping with GCB versus ABC like phenotype. One group with poor clinical outcome was characterized by high expression levels of pro-and anti-apoptotic genes involved in the intrinsic apoptosis pathway. A 2nd group, also with poor clinical outcome, was characterized by high levels of apoptosis inducing cytotoxic effector genes, possibly reflecting a cellular cytotoxic immune response. The 3rd group showing a favourable outcome was characterized by low expression levels of genes characteristic for both other groups. Our results suggest that chemotherapy refractory DLBCL are characterized either by an intense cellular cytotoxic immune response or by constitutive activation of the intrinsic mediated apoptosis pathway with concomitant downstream inhibition of this apoptosis pathway. Consequently, strategies neutralizing the function of apoptosis-inhibiting proteins might be effective as alternative treatment modality in part of chemotherapy refractory DLBCL. Keywords: expression profiling B lymphomas

2006-12-08 | GSE3892 | GEO

Clinical and molecular characterization of splenic diffuse red pulp lymphomas [Agilent]

Project description:Deep characterization of a large series of splenic diffuse red pulp lymphomas

2017-12-23 | GSE65060 | GEO

Gene expression profiling of HIV and EBV-associated classic Hodgkin lymphomas from Malawi

Project description:Gene expression profiling of HIV and EBV-associated classic Hodgkin lymphomas from Malawi

| PRJNA1225276 | ENA

Molecular and pathological characterisation of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome

Project description:Nijmegen-breakage syndrome (NBS, OMIM #251260) is an autosomal recessive chromosomal instability syndrome characterized by a very distinct phenotype (microcephaly, growth retardation, immunodeficiency) associated with increased predisposition to develop malignancies, particularly of lymphoid origin (by the age of 20 years, over 40% of NBS patients develop cancer). Immunological lineage of lymphomas in NBS significantly differs from Non-Hodgkin Lymphomas (NHL) entities observed in general pediatric population as well as in primary immunodeficiencies. There is a strong predominance of diffuse large B-cell lymphoma (DLBCL) and T cell lymphoblastic lymphoma (T-LBL/ALL), all showing clonal Ig/TCR rearrangements. In the current study we aimed to examined gene expression signature of metabolic pathways in DLBCL cells.

2024-08-23 | GSE213555 | GEO

Oncogenic role of the DNMT1 in diffuse large B-cell lymphomas [BSRR]

Project description:Oncogenic role of the DNMT1 in diffuse large B-cell lymphomas [BSRR]

| PRJNA1230146 | ENA