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ABSTRACT: microbiome to improve high fat diet induced obesity

PROVIDER: PRJNA1203435 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31838323_1.fastq.gz	Fastqsanger.gz
	SRR31838323_2.fastq.gz	Fastqsanger.gz
	SRR31838324_1.fastq.gz	Fastqsanger.gz
	SRR31838324_2.fastq.gz	Fastqsanger.gz
	SRR31838325_1.fastq.gz	Fastqsanger.gz

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Project description:The C57BL/6J mouse model develops obesity and pre-diabetes when fed a high-fat diet. In this experiment, DNA methylation was assessed globally at specific CpG sites in liver tissue from mice receiving high-fat diet (45E% from fat) for 13 weeks (Control) or high-fat diet supplemented with 20% (w/w) of freeze-dried lingonberries (n=4). Our findings show that lingonberries prevent development of high-fat induced obesity, hepatic steatosis and low-grade inflammation, and the DNA was hypermethylated in mice receiving lingonberries compared to control. Genome wide hepatic DNA methylation comparison between mice fed high-fat diet with or without a lingonberry supplement (n=4/group).

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