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ABSTRACT: Amomum tsaoko flavonoids altered the structure of the gut microbial community in DSS-induced ulcerative colitis mice

PROVIDER: PRJNA1204908 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31862000_1.fastq.gz	Fastqsanger.gz
	SRR31862000_2.fastq.gz	Fastqsanger.gz
	SRR31862001_1.fastq.gz	Fastqsanger.gz
	SRR31862001_2.fastq.gz	Fastqsanger.gz
	SRR31862002_1.fastq.gz	Fastqsanger.gz

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Dextran sodium sulfate treatment of wild type and Pirc rats alters colonic normal tissue gene expression

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Dextran sodium sulfate treatment of wild type and Pirc rats alters colonic normal tissue gene expression

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Project description:Temporal genome profiling of DSS colitis The DSS induced mouse colitis model is often used to emulate Ulcerative Colitis (UC) in order understand pathophysiological mechanism of inflammatory bowel disease (IBD). Given the progressive nature of IBD, colon tissue gene expression changes during the evolution of disease, and knowing the changes in gene expression profiles could indentify potential diagnostic markers or additional therapeutic targets for colitis. Therefore, we performed temporal genome expression profiling analysis using the Affymetrix genome wide microarray system to identify broad scale changes in gene expression associated with the development of colitis. Keywords: Expression time course of mouse colon tissue induced by 3% DSS. C57BL/6J mice were given 3% DSS in the drinking water and tissues from individual cohorts were collected at days 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymerix GeneChip Mouse Genome 430 2.0 Array.

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