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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D

ABSTRACT: Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D

PROVIDER: PRJNA1204949 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31862072_1.fastq.gz	Fastqsanger.gz
	SRR31862072_2.fastq.gz	Fastqsanger.gz
	SRR31862073_1.fastq.gz	Fastqsanger.gz
	SRR31862073_2.fastq.gz	Fastqsanger.gz
	SRR31862074_1.fastq.gz	Fastqsanger.gz

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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D

Project description:Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. However, there remains limited understanding regarding specific citrullinated proteins and their implications in the progression of RA. In this study, we screened and verified insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein and R167 was the primary citrullination site. Functional verification showed that citrullination at the R167 site of IGF2BP1 promoted the proliferation, migration and invasion of RA fibroblast-like synoviocytes (RA-FLSs). To further explore the specific downstream target of citrullinated IGF2BP1, RNA sequencing was conducted in this study.

2025-01-03 | GSE285602 | GEO

Synovial Gene Signatures Associated with the Development of Rheumatoid Arthritis in At Risk Individuals

Project description:Transcriptional profiling of human synovial tissue from thirteen individuals with arthralgia who were IgM rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positive and without any evidence of arthritis. Survival analysis was used to identify transcripts associated with arthritis after follow up. This study was performed to investigate the molecular changes in synovium preceding arthritis development in at risk individuals.

2022-09-01 | E-MTAB-11874 | biostudies-arrayexpress

Culture effects on rheumatoid arthrits synovial fibroblasts

Project description:Comparison between early passage to later passages of rheumatoid arthritis synovial fibroblast (RASF) populations using two different AtlasTM Human Arrays Gene expression changes during culture with increasing number of changes at higher passages depending on individual expression pattern of the respective cell populations

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Project description:Our study demonstrated that the expression of Igf2bp1 in activated microglia was significantly up-regulated, implying a role of Igf2bp1 in LPS-induced m6A modifications in microglia. To understand the roles of Igf2bp1 on LPS-induced m6A modification in microglia, we performed Igf2bp1 loss-of-function (LOF) approach. Microglia stimulated by LPS were transfected with either scrambled siRNA control or Igf2bp1 siRNA for 48 hours. To m6A modification profiles in control and Igf2bp1 LOF microglia were determined by MeRIP-seq analysis.

2022-12-31 | E-MTAB-11411 | biostudies-arrayexpress

Expression data from Rheumatoid Arthritis synovial tissue samples

Project description:Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Microarray analysis of 83 synovial samples provides insight into the expression-level differences between patients at the site of disease activity. Synovial samples from Rheumatoid Arthritis patients were obtained during joint resection and profiled using microarrays.

2014-04-22 | E-GEOD-48780 | biostudies-arrayexpress

Expression data from rheumatoid arthritis synovial macrophages

Project description:Macrophages from RA synovial fluids were compared to primary human monocyte-derived macrophages.

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Project description:Macrophages from RA synovial fluids were compared to primary human blood-derived macrophages. Keywords: disease state analysis

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Project description:Gene expression microarray was applied to discover novel rheumatoid arthritis (RA)-specific gene expressions by comparing the expression profiles of synovial membranes from patients with RA, osteoarthritis (OA) and ankylosing spondylitis (AS). We performed a gene expression microarray analysis of RA synovial membranes and simultaneously compared the expression profile with the profiles of AS and OA synovial membranes. This study was undertaken to investigate the global gene expression profiles in synovial tissues from RA (n=10), OA (n=7), and AS patients (n=5). The Illumina HumanHT-12 v4 Expression BeadChip were used for a complete genome-wide transcript profiling.

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Indentification of special gene expressions in synovial tissues of rheumatoid arthritis

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Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation.

Project description:Fibroblast-like synoviocytes (FLSs) are critical to synovial aggression and joint destruction in rheumatoid arthritis (RA). The role of long noncoding RNAs (lncRNAs) in RA is largely unknown. Here, we identified a lncRNA, LERFS (lowly expressed in rheumatoid fibroblast-like synoviocytes), that negatively regulates the migration, invasion, and proliferation of FLSs through interaction with heterogeneous nuclear ribonucleoprotein Q (hnRNP Q). Under healthy conditions, by binding to the mRNA of RhoA, Rac1, and CDC42 - the small GTPase proteins that control the motility and proliferation of FLSs - the LERFS-hnRNP Q complex decreased the stability or translation of target mRNAs and downregulated their protein levels. But in RA FLSs, decreased LERFS levels induced a reduction of the LERFS-hnRNP Q complex, which reduced the binding of hnRNP Q to target mRNA and therefore increased the stability or translation of target mRNA. These findings suggest that a decrease in synovial LERFS may contribute to synovial aggression and joint destruction in RA and that targeting the lncRNA LERFS may have therapeutic potential in patients with RA.

| S-EPMC6159954 | biostudies-literature

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