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A distinct subset of the Arabidopsis group S1 basic leucine zipper transcription factors controls plant resource management during starvation and recovery

ABSTRACT: A distinct subset of the Arabidopsis group S1 basic leucine zipper transcription factors controls plant resource management during starvation and recovery

PROVIDER: PRJNA1209578 | ENA |

REPOSITORIES: ENA

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A distinct subset of the Arabidopsis group S1 basic leucine zipper transcription factors controls plant resource management during starvation and recovery

Project description:Plants possess an enormous plasticity to adapt their metabolism to the fluctuating energy supply in a natural environment. Using dark-induced senescence (DIS) as an experimental system, a mutant study combining phenotypical, transcriptomic and Chromatin Immunoprecipitation Sequencing (ChIPseq) approaches identifies distinct members of the Arabidopsis group S1 basic leucine zipper transcription factors that orchestrate the starvation response. While excluding bZIP2, bZIP11 and bZIP44 to function in DIS, the in part redundantly acting bZIP1 and bZIP53 control a co-expression network governing amino acid catabolism and transport, gluconeogenesis and energy homeostasis. Moreover, they regulate genes involved in asparagine – glutamine balance, which are critical for C/N homeostasis. This transcriptional reprogramming in resource management is required for survival during starvation and regaining meristematic activity during recovery from stress. Thus, we provide insights into the transcriptional control of plant resource and energy management during starvation. Finally, this work sheds light on the discrepancy between in vitro DNA-binding and overexpression studies versus mutant analyses and in vivo DNA-binding, providing a critical view on how to define specific transcription factor functions within large families.

2025-07-03 | GSE286485 | GEO

Intricate coupling between the transactivation and basic-leucine zipper domains governs the CK2-dependent phosphorylation of ATF4

Project description:Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of co-activators and co-repressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these mechanisms, the structural and functional basis of transactivation domain in yet poorly understood. Here, we focused on ATF4/CREB-2, an essential transcription factor for cellular stress adaptation. We found that the N-terminal region of the transactivation domain is involved in transient long-range interactions with the basic-leucine zipper domain. In vitro phosphorylation assays with the protein kinase CK2 show that the presence of the basic-leucine zipper domain is required for optimal phosphorylation of the transactivation domain. This study uncovers the intricate coupling existing between the transactivation and basic-leucine zipper domains of ATF4 and highlights its potential functional relevance.

2023-03-11 | PXD029704 | Pride

S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs

Project description:S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs

| PRJNA1060775 | ENA

Deep mutational scanning of the interaction of JUN's leucine zipper domain and other human bZIPs in different experimental conditions

Project description:Deep mutational scanning of the interaction of JUN's leucine zipper domain and other human bZIPs in different experimental conditions

2023-10-18 | GSE245485 | GEO

Immunomodulatory effects of glucocorticoid-induced leucine zipper (GILZ) expression in murine bone-marrow derived macrophages.

Project description:Here, we provide evidence for the immunomodulatory effects of glucocorticoid-induced leucine zipper (GILZ) overexpression in macrophages, demonstrating enhanced antibacterial activity, protection from pyroptosis, and altered mitochondrial function. Additionally, our findings reveal a significant impact on MMP activity, suggesting a role for GILZ in influencing extracellular matrix remodeling and wound healing processes. The study contributes to explorations of GILZ in its significance in pro-resolving macrophage functions.

2024-05-13 | GSE254137 | GEO

Identification of Glucocorticoid-Induced Leucine Zipper (Gilz) gene targets in undifferentiated spermatogonia

Project description:Identification of Glucocorticoid-Induced Leucine Zipper (Gilz) gene targets in undifferentiated spermatogonia

| PRJNA421886 | ENA

Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

Project description:Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

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Leucine starvation series

Project description:These data represent the ratios of charged to total tRNA for E. coli auxotrophic strain CP78 during starvation for leucine over a time course of 32 minutes. Keywords: time-course

2004-12-15 | GSE2065 | GEO

Leucine starvation series

Project description:These data represent the ratios of charged to total tRNA for E. coli auxotrophic strain CP78 during starvation for leucine over a time course of 32 minutes.

2010-05-27 | E-GEOD-2065 | biostudies-arrayexpress

S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs

Project description:To decipher gene expression controlled by the five highly homologous group S1 bZIP transcription factors during the reproductive growth phase of Arabidopsis thaliana, we generated triple (bzip2/-11/-44) and quintuple (bzip1/-2/-11/-44/-53) mutants of these factors using CRISPR/Cas9 and analysed gene expression in distinct C source (source leaves) or C sink (sink leaves, rosette buds, flowers) tissues.

2024-01-12 | GSE252502 | GEO

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