Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The study of somatic LINE1 activity in cancers

ABSTRACT: the study of somatic LINE1 activity in cancers

PROVIDER: PRJNA1210007 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

the study of somatic LINE1 activity in cancers

Project description:the study of somatic LINE1 activity in cancers

| PRJNA1210008 | ENA

LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells

Project description:LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells

| PRJNA839357 | ENA

p53 directly represses human LINE1 transposons

Project description:p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons in germ line tissues of flies and fish but whether this activity is conserved in somatic human cells is not known. Here we show that p53 constitutively restrains human LINE1s by cooperatively engaging sites in the 5’UTR and stimulating local deposition of repressive histone marks at these transposons. Consistent with this, the elimination of p53 or the removal of corresponding binding sites in LINE1s, prompted these retroelements to become hyperactive. Concurrently, p53 loss instigated chromosomal rearrangements linked to LINE sequences and also provoked inflammatory programs that were dependent on reverse transcriptase produced from LINE1s. Taken together, our observations establish that p53 continuously operates at the LINE1 promoter to restrict autonomous copies of these mobile elements in human cells. Our results further suggest that constitutive restriction of these retroelements may help to explain tumor suppression encoded by p53, since erupting LINE1s produced acute oncogenic threats when p53 was absent.

2020-12-01 | GSE159134 | GEO

Effect of LINE1 intervention on vascular calcification （RNA-seq）

Project description:In this study, we report the protective effect of LINE1 intervention on vascular calcification. To elucidate the molecular mechanisms underlying the protective role of LINE1 inhibition, we employed RNA sequencing to identify gene expression changes under LINE1 suppression conditions. Our findings provide insights into the pathways involved in modulating vascular calcification and highlight LINE1 as a potential therapeutic target.

2025-07-15 | GSE279148 | GEO

Somatic Mutation in Normal Bladder Study

Project description:Somatic Mutation in Normal Bladder Study

| PRJNA1278818 | ENA

Somatic Mutation in Normal Bladder Study

Project description:Somatic Mutation in Normal Bladder Study

| PRJNA1278817 | ENA

LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells [RNA-seq]

Project description:LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells [RNA-seq]

| PRJNA839365 | ENA

LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells [MBD-seq]

Project description:LINE1 TGS mechanism mediated by SETDB1-AGO2 complex in human somatic cells [MBD-seq]