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RNA-Seq analysis of germinal center B cells from Tfr-depleted and control kidney transplant recipients

ABSTRACT: RNA-Seq analysis of germinal center B cells from Tfr-depleted and control kidney transplant recipients

PROVIDER: PRJNA1210623 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31998845.fastq.gz	Fastqsanger.gz
	SRR31998846.fastq.gz	Fastqsanger.gz
	SRR31998847.fastq.gz	Fastqsanger.gz
	SRR31998848.fastq.gz	Fastqsanger.gz
	SRR31998849.fastq.gz	Fastqsanger.gz

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RNA-Seq analysis of germinal center B cells from Tfr-depleted and control kidney transplant recipients

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Project description:In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, however, have not been comprehensively studied before. In this study we analyzed sequential liver tissue samples collected from liver recipients enrolled in a prospective multicenter immunosuppressive withdrawal clinical trial. Tolerant and non-tolerant recipients differed in the intra-graft expression of genes involved in the regulation of iron homeostasis.These results point to a critical role of iron homeostasis in the regulation of intra-graft alloimmune responses in humans and provide a set of novel biomarkers to conduct drug-weaning trials in liver transplantation. The complete database comprised the expression measurements of 48766 probes in liver biopsies. The liver biopsy specimens available for the study were obtained: a) before immunosuppressive drugs were discontinued from tolerant (TOL, n=24) and non-tolerant (Non-TOL, n=29) recipients; b) at the time of rejection from non-tolerant recipients (Non TOL REJ, n=18); In addition, liver tissue samples were also collected from the following control patient groups: a) liver transplant recipients with chronic hepatitis due to recurrent hepatitis C virus infection (HEPC, n=12); b) liver transplant recipients with typical acute cellular rejection taking place during the immediate post-transplant period (REJ, n=9); c) liver transplant recipients under maintenance immunosuppression with normal liver function and normal liver histology 1 year after transplantation (CONT-Tx, n=8); and d) non-transplanted patients undergoing surgery for colorectal liver metastases (CONT, n=10).

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