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ABSTRACT: BALF transplantion mogroside-PM2.5-lung microbiome

PROVIDER: PRJNA1210855 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32006722.fastq.gz	Fastqsanger.gz
	SRR32006723.fastq.gz	Fastqsanger.gz
	SRR32006724.fastq.gz	Fastqsanger.gz
	SRR32006725.fastq.gz	Fastqsanger.gz
	SRR32006726.fastq.gz	Fastqsanger.gz

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Project description:mogroside-PM2.5-lung microbiome

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Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer

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Effect of PM2.5 on circRNA expression of HBE cells

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E-MTAB-2751

Project description:Evaluation of gene expression profiling and biochemical response of lung and heart of mice exposed to season fine particulate matter PM2.5

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Distinct exosomal miRNA profiles from BALF and lung tissue from COPD and IPF patients

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Project description:Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and microbiota dysbiosis. However, the function of lung microbiome alteration in early COPD remains unclear. This study is the first to characterize the lower respiratory tract microbiota in early COPD patients via bronchoalveolar lavage fluid (BALF) samples. By using full-length 16S sequencing, we found that the lung microbiome of early COPD patients had lower bacterial richness and significant compositional differences than did that of the healthy smoker controls. Streptococcus was the most robustly distinguished genus in early COPD patients and was associated with decreased lung function and increased host local inflammation. Furthermore, a murine cigarette smoke model of early COPD revealed that Streptococcus mitis promotes the progression of early COPD. Single-cell transcriptomics revealed that Streptococcus mitis increased emphysematous destruction of the lung parenchyma in a mouse early COPD model by regulating the function of alveolar type II (AT2) cells and macrophages. Therefore, targeting the lower airway microbiota in combination with smoking cessation may be a potential therapeutic approach for early COPD.

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