Project description:Calpain 15 (CAPN15), part of the non-classical SOL family, plays a key role in neurodevelopment. This study used RNA-seq in P2 mice (7 KO and 7 WT) to investigate transcriptomic changes after loss of CAPN15. Differential expression analysis identified Pax2 targets as significantly regulated in CAPN15 KO mice. This work provides insight into CAPN15's molecular mechanisms and its potential role in human developmental disorders.
Project description:This SuperSeries is composed of the following subset Series: GSE32050: 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging [5hmC Capture and Seq] GSE32187: 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging [mRNA profiling] Refer to individual Series